Akey DL - Search Results

1

Structural basis for macrolactonization by the pikromycin thioesterase.

Akey DL, Kittendorf JD, Giraldes JW, Fecik RA, Sherman DH, Smith JL. Akey DL, et al. Nat Chem Biol. 2006 Oct;2(10):537-42. doi: 10.1038/nchembio824. Epub 2006 Sep 10. Nat Chem Biol. 2006. PMID: 16969372

2

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.

Giraldes JW, Akey DL, Kittendorf JD, Sherman DH, Smith JL, Fecik RA. Giraldes JW, et al. Among authors: akey dl. Nat Chem Biol. 2006 Oct;2(10):531-6. doi: 10.1038/nchembio822. Epub 2006 Sep 10. Nat Chem Biol. 2006. PMID: 16969373

3

A 7μm mini-beam improves diffraction data from small or imperfect crystals of macromolecules.

Sanishvili R, Nagarajan V, Yoder D, Becker M, Xu S, Corcoran S, Akey DL, Smith JL, Fischetti RF. Sanishvili R, et al. Among authors: akey dl. Acta Crystallogr D Biol Crystallogr. 2008 Apr;64(Pt 4):425-35. doi: 10.1107/S0907444908001741. Epub 2008 Mar 19. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18391409 Free PMC article.

4

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

Claxton HB, Akey DL, Silver MK, Admiraal SJ, Smith JL. Claxton HB, et al. Among authors: akey dl. J Biol Chem. 2009 Feb 20;284(8):5021-9. doi: 10.1074/jbc.M808604200. Epub 2008 Dec 22. J Biol Chem. 2009. PMID: 19103602 Free PMC article.

5

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Akey DL, et al. Structure. 2010 Jan 13;18(1):94-105. doi: 10.1016/j.str.2009.10.018. Structure. 2010. PMID: 20152156 Free PMC article.

6

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH. Scaglione JB, et al. Among authors: akey dl. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5726-30. doi: 10.1002/anie.201000032. Angew Chem Int Ed Engl. 2010. PMID: 20623733 Free PMC article. No abstract available.

7

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.

Leggans EK, Akey DL, Smith JL, Fecik RA. Leggans EK, et al. Among authors: akey dl. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5939-42. doi: 10.1016/j.bmcl.2010.05.089. Epub 2010 May 25. Bioorg Med Chem Lett. 2010. PMID: 20801036 Free PMC article.

8

A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Akey DL, Li S, Konwerski JR, Confer LA, Bernard SM, Anzai Y, Kato F, Sherman DH, Smith JL. Akey DL, et al. J Mol Biol. 2011 Oct 21;413(2):438-50. doi: 10.1016/j.jmb.2011.08.040. Epub 2011 Aug 23. J Mol Biol. 2011. PMID: 21884704 Free PMC article.

9

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.

Chemler JA, Buchholz TJ, Geders TW, Akey DL, Rath CM, Chlipala GE, Smith JL, Sherman DH. Chemler JA, et al. Among authors: akey dl. J Am Chem Soc. 2012 May 2;134(17):7359-66. doi: 10.1021/ja2112228. Epub 2012 Apr 23. J Am Chem Soc. 2012. PMID: 22480290 Free PMC article.

10

Insights from the sea: structural biology of marine polyketide synthases.

Akey DL, Gehret JJ, Khare D, Smith JL. Akey DL, et al. Nat Prod Rep. 2012 Oct;29(10):1038-49. doi: 10.1039/c2np20016c. Epub 2012 Apr 13. Nat Prod Rep. 2012. PMID: 22498975 Free PMC article. Review.

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