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Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction.
Dierssen M, Gratacòs M, Sahún I, Martín M, Gallego X, Amador-Arjona A, Martínez de Lagrán M, Murtra P, Martí E, Pujana MA, Ferrer I, Dalfó E, Martínez-Cué C, Flórez J, Torres-Peraza JF, Alberch J, Maldonado R, Fillat C, Estivill X. Dierssen M, et al. Among authors: estivill x. Neurobiol Dis. 2006 Nov;24(2):403-18. doi: 10.1016/j.nbd.2006.07.015. Epub 2006 Sep 11. Neurobiol Dis. 2006. PMID: 16963267
5' UTR-region SNP in the NTRK3 gene is associated with panic disorder.
Armengol L, Gratacòs M, Pujana MA, Ribasés M, Martín-Santos R, Estivill X. Armengol L, et al. Among authors: estivill x. Mol Psychiatry. 2002;7(9):928-30. doi: 10.1038/sj.mp.4001134. Mol Psychiatry. 2002. PMID: 12399943 No abstract available.
Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.
Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, Escaramís G, Fernández-Aranda F, Forcano L, Gallego X, González JR, Gorwood P, Hebebrand J, Hinney A, Nacmias B, Puig A, Ribasés M, Ricca V, Romo L, Sorbi S, Versini A, Gratacòs M, Estivill X. Mercader JM, et al. Among authors: estivill x. Hum Mol Genet. 2008 May 1;17(9):1234-44. doi: 10.1093/hmg/ddn013. Epub 2008 Jan 18. Hum Mol Genet. 2008. PMID: 18203754 Clinical Trial.
717 results