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alpha-Hydroxy phosphinyl-based inhibitors of human renin.
Patel DV, Rielly-Gauvin K, Ryono DE, Free CA, Rogers WL, Smith SA, DeForrest JM, Oehl RS, Petrillo EW Jr. Patel DV, et al. Among authors: petrillo ew jr. J Med Chem. 1995 Oct 27;38(22):4557-69. doi: 10.1021/jm00022a022. J Med Chem. 1995. PMID: 7473584
Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety.
Dickson JK Jr, Biller SA, Magnin DR, Petrillo EW Jr, Hillyer JW, Hsieh DC, Lan SJ, Rinehart JK, Gregg RE, Harrity TW, Jolibois KG, Kalinowski SS, Kunselman LK, Mookhtiar KA, Ciosek CP Jr. Dickson JK Jr, et al. Among authors: petrillo ew jr. J Med Chem. 1996 Feb 2;39(3):661-4. doi: 10.1021/jm950735s. J Med Chem. 1996. PMID: 8576906 No abstract available.
(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE.
Karanewsky DS, Badia MC, Cushman DW, DeForrest JM, Dejneka T, Loots MJ, Perri MG, Petrillo EW Jr, Powell JR. Karanewsky DS, et al. Among authors: petrillo ew jr. J Med Chem. 1988 Jan;31(1):204-12. doi: 10.1021/jm00396a033. J Med Chem. 1988. PMID: 3336020
Activated ketone based inhibitors of human renin.
Patel DV, Rielly-Gauvin K, Ryono DE, Free CA, Smith SA, Petrillo EW Jr. Patel DV, et al. Among authors: petrillo ew jr. J Med Chem. 1993 Aug 20;36(17):2431-47. doi: 10.1021/jm00069a001. J Med Chem. 1993. PMID: 8355245
15 results