Shimamura K - Search Results

1

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.

Yoshimoto R, Miyamoto Y, Shimamura K, Ishihara A, Takahashi K, Kotani H, Chen AS, Chen HY, Macneil DJ, Kanatani A, Tokita S. Yoshimoto R, et al. Among authors: shimamura k. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13866-71. doi: 10.1073/pnas.0506104103. Epub 2006 Sep 5. Proc Natl Acad Sci U S A. 2006. PMID: 16954192 Free PMC article.

2

Identification of a stable chemerin analog with potent activity toward ChemR23.

Shimamura K, Matsuda M, Miyamoto Y, Yoshimoto R, Seo T, Tokita S. Shimamura K, et al. Peptides. 2009 Aug;30(8):1529-38. doi: 10.1016/j.peptides.2009.05.030. Epub 2009 Jun 18. Peptides. 2009. PMID: 19540290

3

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.

Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):34-41. doi: 10.1016/j.ejphar.2009.12.033. Epub 2010 Jan 4. Eur J Pharmacol. 2010. PMID: 20045404

4

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.

Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S. Shimamura K, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):249-56. doi: 10.1124/jpet.109.150854. Epub 2009 Apr 9. J Pharmacol Exp Ther. 2009. PMID: 19359527

5

(-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells.

Ito M, Ito J, Kitazawa H, Shimamura K, Fukami T, Tokita S, Shimokawa K, Yamada K, Kanatani A, Uemura D. Ito M, et al. Among authors: shimamura k. Peptides. 2009 Jun;30(6):1074-81. doi: 10.1016/j.peptides.2009.02.008. Epub 2009 Feb 21. Peptides. 2009. PMID: 19463739

6

High-throughput assay for long chain fatty acyl-CoA elongase using homogeneous scintillation proximity format.

Shimamura K, Miyamoto Y, Kitazawa H, Kobayashi T, Kotani H, Tokita S. Shimamura K, et al. Assay Drug Dev Technol. 2009 Apr;7(2):124-32. doi: 10.1089/adt.2008.181. Assay Drug Dev Technol. 2009. PMID: 19505229

7

Development of a high-density assay for long-chain fatty acyl-CoA elongases.

Kitazawa H, Miyamoto Y, Shimamura K, Nagumo A, Tokita S. Kitazawa H, et al. Among authors: shimamura k. Lipids. 2009 Aug;44(8):765-73. doi: 10.1007/s11745-009-3320-8. Epub 2009 Jul 4. Lipids. 2009. PMID: 19575253

8

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: shimamura k. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

9

Identification and characterization of a selective radioligand for ELOVL6.

Shimamura K, Takahashi H, Kitazawa H, Miyamoto Y, Nagumo A, Tang C, Dean D, Nagase T, Sato N, Tokita S. Shimamura K, et al. J Biochem. 2009 Sep;146(3):429-37. doi: 10.1093/jb/mvp088. Epub 2009 Jun 8. J Biochem. 2009. PMID: 19505953

10

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Nagase T, et al. Among authors: shimamura k. J Med Chem. 2009 Jul 23;52(14):4111-4. doi: 10.1021/jm900488k. J Med Chem. 2009. PMID: 19522500

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