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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. Leone TC, et al. Among authors: chen z. PLoS Biol. 2005 Apr;3(4):e101. doi: 10.1371/journal.pbio.0030101. Epub 2005 Mar 15. PLoS Biol. 2005. PMID: 15760270 Free PMC article.
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