Manfra D - Search Results

1

Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse.

Hyde LA, McHugh NA, Chen J, Zhang Q, Manfra D, Nomeir AA, Josien H, Bara T, Clader JW, Zhang L, Parker EM, Higgins GA. Hyde LA, et al. Among authors: manfra d. J Pharmacol Exp Ther. 2006 Dec;319(3):1133-43. doi: 10.1124/jpet.106.111716. Epub 2006 Aug 31. J Pharmacol Exp Ther. 2006. PMID: 16946102

2

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Wong GT, et al. Among authors: manfra d. J Biol Chem. 2004 Mar 26;279(13):12876-82. doi: 10.1074/jbc.M311652200. Epub 2004 Jan 6. J Biol Chem. 2004. PMID: 14709552 Free article.

3

Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma.

Yang TY, Chen SC, Leach MW, Manfra D, Homey B, Wiekowski M, Sullivan L, Jenh CH, Narula SK, Chensue SW, Lira SA. Yang TY, et al. Among authors: manfra d. J Exp Med. 2000 Feb 7;191(3):445-54. doi: 10.1084/jem.191.3.445. J Exp Med. 2000. PMID: 10662790 Free PMC article.

4

Role of nitric oxide on eosinophilic lung inflammation in allergic mice.

Feder LS, Stelts D, Chapman RW, Manfra D, Crawley Y, Jones H, Minnicozzi M, Fernandez X, Paster T, Egan RW, Kreutner W, Kung TT. Feder LS, et al. Among authors: manfra d. Am J Respir Cell Mol Biol. 1997 Oct;17(4):436-42. doi: 10.1165/ajrcmb.17.4.2845. Am J Respir Cell Mol Biol. 1997. PMID: 9376118

5

Regulatory effects of interleukin-4 and interleukin-10 on human neutrophil function ex vivo and on neutrophil influx in a rat model of arthritis.

Bober LA, Rojas-Triana A, Jackson JV, Leach MW, Manfra D, Narula SK, Grace MJ. Bober LA, et al. Among authors: manfra d. Arthritis Rheum. 2000 Dec;43(12):2660-7. doi: 10.1002/1529-0131(200012)43:12<2660::AID-ANR5>3.0.CO;2-4. Arthritis Rheum. 2000. PMID: 11145023 Free article.

6

Conditional expression of murine Flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice.

Manfra DJ, Chen SC, Jensen KK, Fine JS, Wiekowski MT, Lira SA. Manfra DJ, et al. J Immunol. 2003 Mar 15;170(6):2843-52. doi: 10.4049/jimmunol.170.6.2843. J Immunol. 2003. PMID: 12626534

7

Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice.

Chen SC, Vassileva G, Kinsley D, Holzmann S, Manfra D, Wiekowski MT, Romani N, Lira SA. Chen SC, et al. Among authors: manfra d. J Immunol. 2002 Feb 1;168(3):1001-8. doi: 10.4049/jimmunol.168.3.1001. J Immunol. 2002. PMID: 11801632

8

Disruption of neutrophil migration in a conditional transgenic model: evidence for CXCR2 desensitization in vivo.

Wiekowski MT, Chen SC, Zalamea P, Wilburn BP, Kinsley DJ, Sharif WW, Jensen KK, Hedrick JA, Manfra D, Lira SA. Wiekowski MT, et al. Among authors: manfra d. J Immunol. 2001 Dec 15;167(12):7102-10. doi: 10.4049/jimmunol.167.12.7102. J Immunol. 2001. PMID: 11739532

9

Leukocytes expressing green fluorescent protein as novel reagents for adoptive cell transfer and bone marrow transplantation studies.

Manfra DJ, Chen SC, Yang TY, Sullivan L, Wiekowski MT, Abbondanzo S, Vassileva G, Zalamea P, Cook DN, Lira SA. Manfra DJ, et al. Am J Pathol. 2001 Jan;158(1):41-7. doi: 10.1016/S0002-9440(10)63942-9. Am J Pathol. 2001. PMID: 11141477 Free PMC article.

10

Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: role for p38 kinase.

Engstrom L, Pinzon-Ortiz MC, Li Y, Chen SC, Kinsley D, Nelissen R, Fine JS, Mihara K, Manfra D. Engstrom L, et al. Among authors: manfra d. Int Immunopharmacol. 2009 Sep;9(10):1218-27. doi: 10.1016/j.intimp.2009.07.003. Epub 2009 Jul 16. Int Immunopharmacol. 2009. PMID: 19616132

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