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Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O. Husson H, et al. Among authors: beier dr. Hum Mol Genet. 2016 Jun 1;25(11):2245-2255. doi: 10.1093/hmg/ddw093. Epub 2016 Apr 5. Hum Mol Genet. 2016. PMID: 27053712 Free PMC article.
Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.
Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR. Manning DK, et al. Among authors: beier dr. J Am Soc Nephrol. 2013 Jan;24(1):100-12. doi: 10.1681/ASN.2012050490. J Am Soc Nephrol. 2013. PMID: 23274954 Free PMC article.
Defects in ciliary localization of Nek8 is associated with cystogenesis.
Trapp ML, Galtseva A, Manning DK, Beier DR, Rosenblum ND, Quarmby LM. Trapp ML, et al. Among authors: beier dr. Pediatr Nephrol. 2008 Mar;23(3):377-87. doi: 10.1007/s00467-007-0692-y. Epub 2008 Jan 9. Pediatr Nephrol. 2008. PMID: 18189147 Free PMC article.
182 results