Jarho EM - Search Results

1

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Juntunen J, Yli-Kokko AL, Vepsäläinen J, Christiaans JA, Forsberg MM, Järvinen T, Männistö PT, Wallén EA. Jarho EM, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5590-3. doi: 10.1016/j.bmcl.2006.08.029. Epub 2006 Aug 17. Bioorg Med Chem Lett. 2006. PMID: 16919454

2

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

Huhtiniemi T, Suuronen T, Rinne VM, Wittekindt C, Lahtela-Kakkonen M, Jarho E, Wallén EA, Salminen A, Poso A, Leppänen J. Huhtiniemi T, et al. J Med Chem. 2008 Aug 14;51(15):4377-80. doi: 10.1021/jm800639h. Epub 2008 Jul 22. J Med Chem. 2008. PMID: 18642893

3

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

Wallén EA, Christiaans JA, Saarinen TJ, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. Wallén EA, et al. Among authors: jarho em. Bioorg Med Chem. 2003 Aug 15;11(17):3611-9. doi: 10.1016/s0968-0896(03)00363-8. Bioorg Med Chem. 2003. PMID: 12901906

4

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.

Wallén EA, Christiaans JA, Jarho EM, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J. Wallén EA, et al. Among authors: jarho em. J Med Chem. 2003 Oct 9;46(21):4543-51. doi: 10.1021/jm030811o. J Med Chem. 2003. PMID: 14521416

5

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site.

Venäläinen JI, Juvonen RO, Garcia-Horsman JA, Wallén EA, Christiaans JA, Jarho EM, Gynther J, Männistö PT. Venäläinen JI, et al. Among authors: jarho em. Biochem J. 2004 Sep 15;382(Pt 3):1003-8. doi: 10.1042/BJ20040992. Biochem J. 2004. PMID: 15217351 Free PMC article.

6

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Huuskonen J, Christiaans JA, Garcia-Horsman JA, Forsberg MM, Järvinen T, Gynther J, Männistö PT, Wallén EA. Jarho EM, et al. J Med Chem. 2004 Nov 4;47(23):5605-7. doi: 10.1021/jm049503w. J Med Chem. 2004. PMID: 15509157

7

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

Jarho EM, Wallén EA, Christiaans JA, Forsberg MM, Venäläinen JI, Männistö PT, Gynther J, Poso A. Jarho EM, et al. J Med Chem. 2005 Jul 28;48(15):4772-82. doi: 10.1021/jm0500020. J Med Chem. 2005. PMID: 16033257

8

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

Venäläinen JI, Garcia-Horsman JA, Forsberg MM, Jalkanen A, Wallén EA, Jarho EM, Christiaans JA, Gynther J, Männistö PT. Venäläinen JI, et al. Among authors: jarho em. Biochem Pharmacol. 2006 Feb 28;71(5):683-92. doi: 10.1016/j.bcp.2005.11.029. Epub 2006 Jan 6. Biochem Pharmacol. 2006. PMID: 16405869

9

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors.

Jarho EM, Venäläinen JI, Poutiainen S, Leskinen H, Vepsäläinen J, Christiaans JA, Forsberg MM, Männistö PT, Wallén EA. Jarho EM, et al. Bioorg Med Chem. 2007 Mar 1;15(5):2024-31. doi: 10.1016/j.bmc.2006.12.036. Epub 2006 Dec 24. Bioorg Med Chem. 2007. PMID: 17215128

10

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats.

Jalkanen AJ, Puttonen KA, Venäläinen JI, Sinervä V, Mannila A, Ruotsalainen S, Jarho EM, Wallén EA, Männistö PT. Jalkanen AJ, et al. Among authors: jarho em. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):132-8. doi: 10.1111/j.1742-7843.2006.00021.x. Basic Clin Pharmacol Toxicol. 2007. PMID: 17244263 Free article.

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