Felix JP - Search Results

1

Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.

Felix JP, Liu J, Schmalhofer WA, Bailey T, Bednarek MA, Kinkel S, Weinglass AB, Kohler M, Kaczorowski GJ, Priest BT, Garcia ML. Felix JP, et al. Biochemistry. 2006 Aug 22;45(33):10129-39. doi: 10.1021/bi060509s. Biochemistry. 2006. PMID: 16906771

2

Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.

Schmalhofer WA, Bao J, McManus OB, Green B, Matyskiela M, Wunderler D, Bugianesi RM, Felix JP, Hanner M, Linde-Arias AR, Ponte CG, Velasco L, Koo G, Staruch MJ, Miao S, Parsons WH, Rupprecht K, Slaughter RS, Kaczorowski GJ, Garcia ML. Schmalhofer WA, et al. Among authors: felix jp. Biochemistry. 2002 Jun 18;41(24):7781-94. doi: 10.1021/bi025722c. Biochemistry. 2002. PMID: 12056910

3

Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, K(v)1.3.

Schmalhofer WA, Slaughter RS, Matyskiela M, Felix JP, Tang YS, Rupprecht K, Kaczorowski GJ, Garcia ML. Schmalhofer WA, et al. Among authors: felix jp. Biochemistry. 2003 Apr 29;42(16):4733-43. doi: 10.1021/bi034122q. Biochemistry. 2003. PMID: 12705837

4

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML. Middleton RE, et al. Among authors: felix jp. Biochemistry. 2003 Nov 25;42(46):13698-707. doi: 10.1021/bi035209e. Biochemistry. 2003. PMID: 14622016

5

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

Priest BT, Garcia ML, Middleton RE, Brochu RM, Clark S, Dai G, Dick IE, Felix JP, Liu CJ, Reiseter BS, Schmalhofer WA, Shao PP, Tang YS, Chou MZ, Kohler MG, Smith MM, Warren VA, Williams BS, Cohen CJ, Martin WJ, Meinke PT, Parsons WH, Wafford KA, Kaczorowski GJ. Priest BT, et al. Among authors: felix jp. Biochemistry. 2004 Aug 3;43(30):9866-76. doi: 10.1021/bi0493259. Biochemistry. 2004. PMID: 15274641

6

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

Williams BS, Felix JP, Priest BT, Brochu RM, Dai K, Hoyt SB, London C, Tang YS, Duffy JL, Parsons WH, Kaczorowski GJ, Garcia ML. Williams BS, et al. Among authors: felix jp. Biochemistry. 2007 Dec 18;46(50):14693-703. doi: 10.1021/bi7018207. Epub 2007 Nov 21. Biochemistry. 2007. PMID: 18027973

7

The inwardly rectifying potassium channel Kir1.1: development of functional assays to identify and characterize channel inhibitors.

Felix JP, Priest BT, Solly K, Bailey T, Brochu RM, Liu CJ, Kohler MG, Kiss L, Alonso-Galicia M, Tang H, Pasternak A, Kaczorowski GJ, Garcia ML. Felix JP, et al. Assay Drug Dev Technol. 2012 Oct;10(5):417-31. doi: 10.1089/adt.2012.462. Epub 2012 Aug 10. Assay Drug Dev Technol. 2012. PMID: 22881347

8

Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells.

Helms LM, Felix JP, Bugianesi RM, Garcia ML, Stevens S, Leonard RJ, Knaus HG, Koch R, Wanner SG, Kaczorowski GJ, Slaughter RS. Helms LM, et al. Among authors: felix jp. Biochemistry. 1997 Mar 25;36(12):3737-44. doi: 10.1021/bi962351p. Biochemistry. 1997. PMID: 9132027

9

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.

Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, Bao JM, Kayser F, Parsons WH, Rupprecht K, Garcia ML, Kaczorowski GJ, Slaughter RS. Felix JP, et al. Biochemistry. 1999 Apr 20;38(16):4922-30. doi: 10.1021/bi982954w. Biochemistry. 1999. PMID: 10213593

10

Binding of correolide to the K(v)1.3 potassium channel: characterization of the binding domain by site-directed mutagenesis.

Hanner M, Green B, Gao YD, Schmalhofer WA, Matyskiela M, Durand DJ, Felix JP, Linde AR, Bordallo C, Kaczorowski GJ, Kohler M, Garcia ML. Hanner M, et al. Among authors: felix jp. Biochemistry. 2001 Oct 2;40(39):11687-97. doi: 10.1021/bi0111698. Biochemistry. 2001. PMID: 11570869

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