Sobol E - Search Results

1

Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug.

Sobol E, Yagen B, Steve White H, Wilcox KS, Lamb JG, Pappo O, Wlodarczyk BJ, Finnell RH, Bialer M. Sobol E, et al. Neuropharmacology. 2006 Sep;51(4):933-46. doi: 10.1016/j.neuropharm.2006.06.006. Epub 2006 Aug 4. Neuropharmacology. 2006. PMID: 16890251

2

Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.

Sobol E, Bialer M, Yagen B. Sobol E, et al. J Med Chem. 2004 Aug 12;47(17):4316-26. doi: 10.1021/jm0498351. J Med Chem. 2004. PMID: 15294003

3

Pharmacokinetics and metabolism of a new potent antiepileptic drug, 2,2,3,3-tetramethycyclopropanecarbonylurea, in rats.

Sobol E, Yagen B, Winkler I, Britzi M, Gibson D, Bialer M. Sobol E, et al. Drug Metab Dispos. 2005 Oct;33(10):1538-46. doi: 10.1124/dmd.105.005637. Epub 2005 Jul 21. Drug Metab Dispos. 2005. PMID: 16037415

4

Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain.

Winkler I, Sobol E, Yagen B, Steinman A, Devor M, Bialer M. Winkler I, et al. Among authors: sobol e. Neuropharmacology. 2005 Dec;49(8):1110-20. doi: 10.1016/j.neuropharm.2005.06.008. Epub 2005 Aug 1. Neuropharmacology. 2005. PMID: 16055160

5

Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide.

Sobol E, Yagen B, Lamb JG, White HS, Wlodarczyk BJ, Finnell RH, Bialer M. Sobol E, et al. Epilepsy Res. 2007 Jan;73(1):75-84. doi: 10.1016/j.eplepsyres.2006.08.004. Epub 2006 Sep 25. Epilepsy Res. 2007. PMID: 16997532

6

The relationships between half-life (t1/2) and mean residence time (MRT) in the two-compartment open body model.

Sobol E, Bialer M. Sobol E, et al. Biopharm Drug Dispos. 2004 May;25(4):157-62. doi: 10.1002/bdd.396. Biopharm Drug Dispos. 2004. PMID: 15108218

7

The activity of antiepileptic drugs as histone deacetylase inhibitors.

Eyal S, Yagen B, Sobol E, Altschuler Y, Shmuel M, Bialer M. Eyal S, et al. Among authors: sobol e. Epilepsia. 2004 Jul;45(7):737-44. doi: 10.1111/j.0013-9580.2004.00104.x. Epilepsia. 2004. PMID: 15230695 Free article.

8

Mathematical comparison between volume of distribution (V) and volume of distribution at steady-state (Vss) utilizing model-independent approach.

Sobol E, Bialer M. Sobol E, et al. Biopharm Drug Dispos. 2004 Mar;25(2):99-101. doi: 10.1002/bdd.372. Biopharm Drug Dispos. 2004. PMID: 14872558

9

Critical analysis of the discrepancy between V(beta) and V(ss) for drugs exhibiting different two-compartment disposition profiles.

Sobol E, Bialer M. Sobol E, et al. Biopharm Drug Dispos. 2005 Mar;26(2):51-8. doi: 10.1002/bdd.431. Biopharm Drug Dispos. 2005. PMID: 15614832

10

Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice.

Okada A, Onishi Y, Aoki Y, Yagen B, Sobol E, Bialer M, Fujiwara M. Okada A, et al. Among authors: sobol e. Birth Defects Res B Dev Reprod Toxicol. 2006 Jun;77(3):227-33. doi: 10.1002/bdrb.20078. Birth Defects Res B Dev Reprod Toxicol. 2006. PMID: 16767757

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