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Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio- and chemoresistance by inhibition of the anti-apoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large.
Friesen C, Roscher M, Hormann I, Leib O, Marx S, Moreno J, Miltner E. Friesen C, et al. Eur J Cancer. 2013 Jul;49(11):2542-54. doi: 10.1016/j.ejca.2013.04.008. Epub 2013 May 16. Eur J Cancer. 2013. PMID: 23684782
291 results