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Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis.
Heymans S, Pauschinger M, De Palma A, Kallwellis-Opara A, Rutschow S, Swinnen M, Vanhoutte D, Gao F, Torpai R, Baker AH, Padalko E, Neyts J, Schultheiss HP, Van de Werf F, Carmeliet P, Pinto YM. Heymans S, et al. Among authors: schultheiss hp. Circulation. 2006 Aug 8;114(6):565-73. doi: 10.1161/CIRCULATIONAHA.105.591032. Epub 2006 Jul 31. Circulation. 2006. PMID: 16880329
Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction.
Kühl U, Pauschinger M, Schwimmbeck PL, Seeberg B, Lober C, Noutsias M, Poller W, Schultheiss HP. Kühl U, et al. Among authors: schultheiss hp. Circulation. 2003 Jun 10;107(22):2793-8. doi: 10.1161/01.CIR.0000072766.67150.51. Epub 2003 May 27. Circulation. 2003. PMID: 12771005 Clinical Trial.
Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response.
Pauschinger M, Rutschow S, Chandrasekharan K, Westermann D, Weitz A, Peter Schwimmbeck L, Zeichhardt H, Poller W, Noutsias M, Li J, Schultheiss HP, Tschope C. Pauschinger M, et al. Among authors: schultheiss hp. Eur J Heart Fail. 2005 Jun;7(4):444-52. doi: 10.1016/j.ejheart.2004.07.002. Eur J Heart Fail. 2005. PMID: 15921778 Free article.
Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis.
Li J, Leschka S, Rutschow S, Schwimmbeck PL, Husmann L, Noutsias M, Westermann D, Poller W, Zeichhardt H, Klingel K, Tschope C, Schultheiss HP, Pauschinger M. Li J, et al. Among authors: schultheiss hp. Eur J Pharmacol. 2007 Jan 5;554(1):60-8. doi: 10.1016/j.ejphar.2006.08.024. Epub 2006 Aug 26. Eur J Pharmacol. 2007. PMID: 17113076
Left ventricular enlargement in coxsackievirus-B3 induced chronic myocarditis--ongoing inflammation and an imbalance of the matrix degrading system.
Rutschow S, Leschka S, Westermann D, Puhl K, Weitz A, Ladyszenskij L, Jaeger S, Zeichhardt H, Noutsias M, Schultheiss HP, Tschope C, Pauschinger M. Rutschow S, et al. Among authors: schultheiss hp. Eur J Pharmacol. 2010 Mar 25;630(1-3):145-51. doi: 10.1016/j.ejphar.2009.12.019. Epub 2009 Dec 24. Eur J Pharmacol. 2010. PMID: 20035743
Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis.
Tschöpe C, Van Linthout S, Jäger S, Arndt R, Trippel T, Müller I, Elsanhoury A, Rutschow S, Anker SD, Schultheiss HP, Pauschinger M, Spillmann F, Pappritz K. Tschöpe C, et al. Among authors: schultheiss hp. ESC Heart Fail. 2020 Oct;7(5):2838-2852. doi: 10.1002/ehf2.12887. Epub 2020 Jul 14. ESC Heart Fail. 2020. PMID: 32662949 Free PMC article.
595 results