Nutley BP - Search Results

1

Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.

Smith NF, Hayes A, James K, Nutley BP, McDonald E, Henley A, Dymock B, Drysdale MJ, Raynaud FI, Workman P. Smith NF, et al. Among authors: nutley bp. Mol Cancer Ther. 2006 Jun;5(6):1628-37. doi: 10.1158/1535-7163.MCT-06-0041. Mol Cancer Ther. 2006. PMID: 16818523

2

Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice.

Smith NF, Hayes A, Nutley BP, Raynaud FI, Workman P. Smith NF, et al. Among authors: nutley bp. Cancer Chemother Pharmacol. 2004 Dec;54(6):475-86. doi: 10.1007/s00280-004-0853-7. Epub 2004 Jul 29. Cancer Chemother Pharmacol. 2004. PMID: 15526201

3

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.

Nutley BP, Smith NF, Hayes A, Kelland LR, Brunton L, Golding BT, Smith GC, Martin NM, Workman P, Raynaud FI. Nutley BP, et al. Br J Cancer. 2005 Oct 31;93(9):1011-8. doi: 10.1038/sj.bjc.6602823. Br J Cancer. 2005. PMID: 16249792 Free PMC article.

4

Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.

Raynaud FI, Fischer PM, Nutley BP, Goddard PM, Lane DP, Workman P. Raynaud FI, et al. Among authors: nutley bp. Mol Cancer Ther. 2004 Mar;3(3):353-62. Mol Cancer Ther. 2004. PMID: 15026556

5

Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.

Nutley BP, Raynaud FI, Wilson SC, Fischer PM, Hayes A, Goddard PM, McClue SJ, Jarman M, Lane DP, Workman P. Nutley BP, et al. Mol Cancer Ther. 2005 Jan;4(1):125-39. Mol Cancer Ther. 2005. PMID: 15657360

6

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

Raynaud FI, Eccles S, Clarke PA, Hayes A, Nutley B, Alix S, Henley A, Di-Stefano F, Ahmad Z, Guillard S, Bjerke LM, Kelland L, Valenti M, Patterson L, Gowan S, de Haven Brandon A, Hayakawa M, Kaizawa H, Koizumi T, Ohishi T, Patel S, Saghir N, Parker P, Waterfield M, Workman P. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50. doi: 10.1158/0008-5472.CAN-06-4615. Cancer Res. 2007. PMID: 17575152 Free article.

7

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.

Wilson SC, Atrash B, Barlow C, Eccles S, Fischer PM, Hayes A, Kelland L, Jackson W, Jarman M, Mirza A, Moreno J, Nutley BP, Raynaud FI, Sheldrake P, Walton M, Westwood R, Whittaker S, Workman P, McDonald E. Wilson SC, et al. Among authors: nutley bp. Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. doi: 10.1016/j.bmc.2011.08.051. Epub 2011 Aug 31. Bioorg Med Chem. 2011. PMID: 21982796

8

Identification of biliary metabolites of ifosfamide using 31P magnetic resonance spectroscopy and mass spectrometry.

Payne GS, Dzik-Jurasz AS, Mancini L, Nutley B, Raynaud F, Leach MO. Payne GS, et al. Cancer Chemother Pharmacol. 2005 Oct;56(4):409-14. doi: 10.1007/s00280-005-1023-2. Epub 2005 May 5. Cancer Chemother Pharmacol. 2005. PMID: 15877229

9

Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

O'Donnell A, Judson I, Dowsett M, Raynaud F, Dearnaley D, Mason M, Harland S, Robbins A, Halbert G, Nutley B, Jarman M. O'Donnell A, et al. Br J Cancer. 2004 Jun 14;90(12):2317-25. doi: 10.1038/sj.bjc.6601879. Br J Cancer. 2004. PMID: 15150570 Free PMC article. Clinical Trial.

10

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo.

Spruce BA, Campbell LA, McTavish N, Cooper MA, Appleyard MV, O'Neill M, Howie J, Samson J, Watt S, Murray K, McLean D, Leslie NR, Safrany ST, Ferguson MJ, Peters JA, Prescott AR, Box G, Hayes A, Nutley B, Raynaud F, Downes CP, Lambert JJ, Thompson AM, Eccles S. Spruce BA, et al. Cancer Res. 2004 Jul 15;64(14):4875-86. doi: 10.1158/0008-5472.CAN-03-3180. Cancer Res. 2004. PMID: 15256458

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