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Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP. Paulusma CC, et al. Among authors: spijkerboer al. Hepatology. 2006 Jul;44(1):195-204. doi: 10.1002/hep.21212. Hepatology. 2006. PMID: 16799980