Siegel M - Search Results

1

Rational design of combination enzyme therapy for celiac sprue.

Siegel M, Bethune MT, Gass J, Ehren J, Xia J, Johannsen A, Stuge TB, Gray GM, Lee PP, Khosla C. Siegel M, et al. Chem Biol. 2006 Jun;13(6):649-58. doi: 10.1016/j.chembiol.2006.04.009. Chem Biol. 2006. PMID: 16793522

2

Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2.

Siegel M, Xia J, Khosla C. Siegel M, et al. Bioorg Med Chem. 2007 Sep 15;15(18):6253-61. doi: 10.1016/j.bmc.2007.06.020. Epub 2007 Jun 13. Bioorg Med Chem. 2007. PMID: 17590341 Free PMC article.

3

Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue.

Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. Gass J, et al. Among authors: siegel m. Gastroenterology. 2007 Aug;133(2):472-80. doi: 10.1053/j.gastro.2007.05.028. Epub 2007 May 21. Gastroenterology. 2007. PMID: 17681168

4

Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.

Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM. Xia J, et al. Among authors: siegel m. Bioorg Med Chem. 2007 Oct 15;15(20):6565-73. doi: 10.1016/j.bmc.2007.07.001. Epub 2007 Jul 25. Bioorg Med Chem. 2007. PMID: 17681795 Free PMC article.

5

Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.

Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P, Omary B, Rich KM, Khosla C. Choi K, et al. Among authors: siegel m. Chem Biol. 2005 Apr;12(4):469-75. doi: 10.1016/j.chembiol.2005.02.007. Chem Biol. 2005. PMID: 15850984

6

Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin.

Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C. Xia J, et al. Among authors: siegel m. J Am Chem Soc. 2006 Feb 15;128(6):1859-67. doi: 10.1021/ja056423o. J Am Chem Soc. 2006. PMID: 16464085 Free PMC article.

7

Transglutaminase 2 inhibitors and their therapeutic role in disease states.

Siegel M, Khosla C. Siegel M, et al. Pharmacol Ther. 2007 Aug;115(2):232-45. doi: 10.1016/j.pharmthera.2007.05.003. Epub 2007 May 13. Pharmacol Ther. 2007. PMID: 17582505 Free PMC article. Review.

8

Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides.

Bethune MT, Siegel M, Howles-Banerji S, Khosla C. Bethune MT, et al. Among authors: siegel m. J Pharmacol Exp Ther. 2009 May;329(2):657-68. doi: 10.1124/jpet.108.148007. Epub 2009 Feb 13. J Pharmacol Exp Ther. 2009. PMID: 19218531 Free PMC article.

9

Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue.

Pyle GG, Paaso B, Anderson BE, Allen DD, Marti T, Li Q, Siegel M, Khosla C, Gray GM. Pyle GG, et al. Among authors: siegel m. Clin Gastroenterol Hepatol. 2005 Jul;3(7):687-94. doi: 10.1016/s1542-3565(05)00366-6. Clin Gastroenterol Hepatol. 2005. PMID: 16206502 Clinical Trial.

10

Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury.

Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Siegel M, et al. PLoS One. 2008 Mar 26;3(3):e1861. doi: 10.1371/journal.pone.0001861. PLoS One. 2008. PMID: 18365016 Free PMC article.

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