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Page 1
2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.
Serby MD, Zhao H, Szczepankiewicz BG, Kosogof C, Xin Z, Liu B, Liu M, Nelson LT, Kaszubska W, Falls HD, Schaefer V, Bush EN, Shapiro R, Droz BA, Knourek-Segel VE, Fey TA, Brune ME, Beno DW, Turner TM, Collins CA, Jacobson PB, Sham HL, Liu G. Serby MD, et al. Among authors: jacobson pb. J Med Chem. 2006 Apr 20;49(8):2568-78. doi: 10.1021/jm0510934. J Med Chem. 2006. PMID: 16610800
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
Xin Z, Serby MD, Zhao H, Kosogof C, Szczepankiewicz BG, Liu M, Liu B, Hutchins CW, Sarris KA, Hoff ED, Falls HD, Lin CW, Ogiela CA, Collins CA, Brune ME, Bush EN, Droz BA, Fey TA, Knourek-Segel VE, Shapiro R, Jacobson PB, Beno DW, Turner TM, Sham HL, Liu G. Xin Z, et al. Among authors: jacobson pb. J Med Chem. 2006 Jul 27;49(15):4459-69. doi: 10.1021/jm060461g. J Med Chem. 2006. PMID: 16854051
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
Yang R, Wilcox DM, Haasch DL, Jung PM, Nguyen PT, Voorbach MJ, Doktor S, Brodjian S, Bush EN, Lin E, Jacobson PB, Collins CA, Landschulz KT, Trevillyan JM, Rondinone CM, Surowy TK. Yang R, et al. Among authors: jacobson pb. J Biol Chem. 2007 Aug 3;282(31):22765-74. doi: 10.1074/jbc.M700790200. Epub 2007 Jun 5. J Biol Chem. 2007. PMID: 17550900 Free article.
Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Hancock AA, Diehl MS, Fey TA, Bush EN, Faghih R, Miller TR, Krueger KM, Pratt JK, Cowart MD, Dickinson RW, Shapiro R, Knourek-Segel VE, Droz BA, McDowell CA, Krishna G, Brune ME, Esbenshade TA, Jacobson PB. Hancock AA, et al. Among authors: jacobson pb. Inflamm Res. 2005 Apr;54 Suppl 1:S27-9. doi: 10.1007/s00011-004-0412-z. Inflamm Res. 2005. PMID: 15928821 No abstract available.
Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonists.
Hancock AA, Bitner RS, Krueger KM, Otte S, Nikkel AL, Fey TA, Bush EN, Dickinson RW, Shapiro R, Knourek-Segel V, Droz BA, Brune ME, Jacobson PB, Cowart MD, Esbenshade TA. Hancock AA, et al. Among authors: jacobson pb. Inflamm Res. 2006 Apr;55 Suppl 1:S42-4. doi: 10.1007/s00011-005-0034-0. Inflamm Res. 2006. PMID: 16547814 No abstract available.
Delivery of RNAi reagents in murine models of obesity and diabetes.
Wilcox DM, Yang R, Morgan SJ, Nguyen PT, Voorbach MJ, Jung PM, Haasch DL, Lin E, Bush EN, Opgenorth TJ, Jacobson PB, Collins CA, Rondinone CM, Surowy T, Landschulz KT. Wilcox DM, et al. Among authors: jacobson pb. J RNAi Gene Silencing. 2006 Nov 29;3(1):225-36. J RNAi Gene Silencing. 2006. PMID: 19771218 Free PMC article.
Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.
Yeh VS, Kurukulasuriya R, Fung S, Monzon K, Chiou W, Wang J, Stolarik D, Imade H, Shapiro R, Knourek-Segel V, Bush E, Wilcox D, Nguyen PT, Brune M, Jacobson P, Link JT. Yeh VS, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5555-60. doi: 10.1016/j.bmcl.2006.08.034. Epub 2006 Aug 23. Bioorg Med Chem Lett. 2006. PMID: 16931002
Histamine H(3) antagonists in models of obesity.
Hancock AA, Bush EN, Jacobson PB, Faghih R, Esbenshade TA. Hancock AA, et al. Among authors: jacobson pb. Inflamm Res. 2004 Mar;53 Suppl 1:S47-8. doi: 10.1007/s00011-003-0322-5. Epub 2004 Mar 5. Inflamm Res. 2004. PMID: 15054613 No abstract available.
63 results