Ryan AJ - Search Results

1

ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer model.

Matsumori Y, Yano S, Goto H, Nakataki E, Wedge SR, Ryan AJ, Sone S. Matsumori Y, et al. Among authors: ryan aj. Oncol Res. 2006;16(1):15-26. doi: 10.3727/000000006783981260. Oncol Res. 2006. PMID: 16783964

2

Antitumor vascular strategy for controlling experimental metastatic spread of human small-cell lung cancer cells with ZD6474 in natural killer cell-depleted severe combined immunodeficient mice.

Yano S, Muguruma H, Matsumori Y, Goto H, Nakataki E, Edakuni N, Tomimoto H, Kakiuchi S, Yamamoto A, Uehara H, Ryan A, Sone S. Yano S, et al. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8789-98. doi: 10.1158/1078-0432.CCR-05-0674. Clin Cancer Res. 2005. PMID: 16361567

3

Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.

Ogino H, Yano S, Kakiuchi S, Yamada T, Ikuta K, Nakataki E, Goto H, Hanibuchi M, Nishioka Y, Ryan A, Sone S. Ogino H, et al. Cancer Lett. 2008 Jun 28;265(1):55-66. doi: 10.1016/j.canlet.2008.02.018. Epub 2008 Mar 24. Cancer Lett. 2008. PMID: 18364248

4

Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model.

Conrad C, Ischenko I, Köhl G, Wiegand U, Guba M, Yezhelyev M, Ryan AJ, Barge A, Geissler EK, Wedge SR, Jauch KW, Bruns CJ. Conrad C, et al. Among authors: ryan aj. Anticancer Drugs. 2007 Jun;18(5):569-79. doi: 10.1097/CAD.0b013e3280147d13. Anticancer Drugs. 2007. PMID: 17414626

5

The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma.

Drevs J, Konerding MA, Wolloscheck T, Wedge SR, Ryan AJ, Ogilvie DJ, Esser N. Drevs J, et al. Among authors: ryan aj. Angiogenesis. 2004;7(4):347-54. doi: 10.1007/s10456-005-1394-3. Epub 2005 May 9. Angiogenesis. 2004. PMID: 15886878

6

ZD6474--a novel inhibitor of VEGFR and EGFR tyrosine kinase activity.

Ryan AJ, Wedge SR. Ryan AJ, et al. Br J Cancer. 2005 Jun;92 Suppl 1(Suppl 1):S6-13. doi: 10.1038/sj.bjc.6602603. Br J Cancer. 2005. PMID: 15928657 Free PMC article. Review.

7

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.

Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. Goodlad RA, et al. Among authors: ryan aj. Carcinogenesis. 2006 Oct;27(10):2133-9. doi: 10.1093/carcin/bgl113. Epub 2006 Jun 16. Carcinogenesis. 2006. PMID: 16782971

8

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.

Alferez DG, Goodlad RA, Odedra R, Sini P, Crafter C, Ryan AJ, Wedge SR, Wright NA, Anderson E, Wilkinson RW. Alferez DG, et al. Among authors: ryan aj. Int J Oncol. 2012 Oct;41(4):1475-85. doi: 10.3892/ijo.2012.1580. Epub 2012 Jul 31. Int J Oncol. 2012. PMID: 22858681

9

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. Alferez D, et al. Among authors: ryan aj. Mol Cancer Ther. 2008 Mar;7(3):590-8. doi: 10.1158/1535-7163.MCT-07-0433. Mol Cancer Ther. 2008. PMID: 18347145

10

DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models.

Jiang Y, Willmore E, Wedge SR, Ryan AJ. Jiang Y, et al. Among authors: ryan aj. Mol Cancer Ther. 2021 Sep;20(9):1663-1671. doi: 10.1158/1535-7163.MCT-20-0857. Epub 2021 Jun 22. Mol Cancer Ther. 2021. PMID: 34158348 Free PMC article.

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