Kozielski F - Search Results

1

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.

Brier S, Lemaire D, DeBonis S, Forest E, Kozielski F. Brier S, et al. Among authors: kozielski f. J Mol Biol. 2006 Jul 7;360(2):360-76. doi: 10.1016/j.jmb.2006.04.062. Epub 2006 May 15. J Mol Biol. 2006. PMID: 16780877

2

The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations.

Kozielski F, De Bonis S, Burmeister WP, Cohen-Addad C, Wade RH. Kozielski F, et al. Structure. 1999 Nov 15;7(11):1407-16. doi: 10.1016/s0969-2126(00)80030-1. Structure. 1999. PMID: 10574799 Free article.

3

Structural links to kinesin directionality and movement.

Wade RH, Kozielski F. Wade RH, et al. Among authors: kozielski f. Nat Struct Biol. 2000 Jun;7(6):456-60. doi: 10.1038/75850. Nat Struct Biol. 2000. PMID: 10881190 Review.

4

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

DeBonis S, Simorre JP, Crevel I, Lebeau L, Skoufias DA, Blangy A, Ebel C, Gans P, Cross R, Hackney DD, Wade RH, Kozielski F. DeBonis S, et al. Among authors: kozielski f. Biochemistry. 2003 Jan 21;42(2):338-49. doi: 10.1021/bi026716j. Biochemistry. 2003. PMID: 12525161 Free article.

5

Crystal structure of the motor domain of the human kinetochore protein CENP-E.

Garcia-Saez I, Yen T, Wade RH, Kozielski F. Garcia-Saez I, et al. Among authors: kozielski f. J Mol Biol. 2004 Jul 23;340(5):1107-16. doi: 10.1016/j.jmb.2004.05.053. J Mol Biol. 2004. PMID: 15236970

6

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

DeBonis S, Skoufias DA, Lebeau L, Lopez R, Robin G, Margolis RL, Wade RH, Kozielski F. DeBonis S, et al. Among authors: kozielski f. Mol Cancer Ther. 2004 Sep;3(9):1079-90. Mol Cancer Ther. 2004. PMID: 15367702

7

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

Brier S, Lemaire D, Debonis S, Forest E, Kozielski F. Brier S, et al. Among authors: kozielski f. Biochemistry. 2004 Oct 19;43(41):13072-82. doi: 10.1021/bi049264e. Biochemistry. 2004. PMID: 15476401

8

Essential kinesins: characterization of Caenorhabditis elegans KLP-15.

Robin G, DeBonis S, Dornier A, Cappello G, Ebel C, Wade RH, Thierry-Mieg D, Kozielski F. Robin G, et al. Among authors: kozielski f. Biochemistry. 2005 May 3;44(17):6526-36. doi: 10.1021/bi048157h. Biochemistry. 2005. PMID: 15850386

9

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5.

Brier S, Lemaire D, DeBonis S, Kozielski F, Forest E. Brier S, et al. Among authors: kozielski f. Rapid Commun Mass Spectrom. 2006;20(3):456-62. doi: 10.1002/rcm.2329. Rapid Commun Mass Spectrom. 2006. PMID: 16402342

10

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

Skoufias DA, DeBonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D, Kozielski F. Skoufias DA, et al. Among authors: kozielski f. J Biol Chem. 2006 Jun 30;281(26):17559-69. doi: 10.1074/jbc.M511735200. Epub 2006 Feb 28. J Biol Chem. 2006. PMID: 16507573 Free article.

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