Le Pla RC - Search Results

1

Detection and quantitation of benzo[a]pyrene-derived DNA adducts in mouse liver by liquid chromatography-tandem mass spectrometry: comparison with 32P-postlabeling.

Singh R, Gaskell M, Le Pla RC, Kaur B, Azim-Araghi A, Roach J, Koukouves G, Souliotis VL, Kyrtopoulos SA, Farmer PB. Singh R, et al. Among authors: le pla rc. Chem Res Toxicol. 2006 Jun;19(6):868-78. doi: 10.1021/tx060011r. Chem Res Toxicol. 2006. PMID: 16780367

2

Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples.

Le Pla RC, Ritchie KJ, Henderson CJ, Wolf CR, Harrington CF, Farmer PB. Le Pla RC, et al. Chem Res Toxicol. 2007 Aug;20(8):1177-82. doi: 10.1021/tx700088j. Epub 2007 Jul 18. Chem Res Toxicol. 2007. PMID: 17636892

3

Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry.

Harrington CF, Le Pla RC, Jones GD, Thomas AL, Farmer PB. Harrington CF, et al. Among authors: le pla rc. Chem Res Toxicol. 2010 Aug 16;23(8):1313-21. doi: 10.1021/tx100023c. Chem Res Toxicol. 2010. PMID: 20666396

4

Further development of 32P-postlabeling for the detection of alkylphosphotriesters: evidence for the long-term nonrandom persistence of ethyl-phosphotriester adducts in vivo.

Le Pla RC, Guichard Y, Bowman KJ, Gaskell M, Farmer PB, Jones GD. Le Pla RC, et al. Chem Res Toxicol. 2004 Nov;17(11):1491-500. doi: 10.1021/tx049798g. Chem Res Toxicol. 2004. PMID: 15540947

5

Phosphate alkylation in different DNA substrates: the role of local DNA sequence and electrophile character in determining the nonrandom nature of phosphotriester adduct formation.

Le Pla RC, Bowman KJ, Farmer PB, Jones GD. Le Pla RC, et al. Chem Res Toxicol. 2006 Mar;19(3):407-13. doi: 10.1021/tx050298c. Chem Res Toxicol. 2006. PMID: 16544945

6

Phosphotriester adducts (PTEs): DNA's overlooked lesion.

Jones GD, Le Pla RC, Farmer PB. Jones GD, et al. Among authors: le pla rc. Mutagenesis. 2010 Jan;25(1):3-16. doi: 10.1093/mutage/gep038. Epub 2009 Nov 17. Mutagenesis. 2010. PMID: 19920061 Review.

7

Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking.

LePla RC, Landreau CA, Shipman M, Hartley JA, Jones GD. LePla RC, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2861-4. doi: 10.1016/j.bmcl.2005.03.091. Epub 2005 Apr 25. Bioorg Med Chem Lett. 2005. PMID: 15911269

8

On the origin of the DNA sequence selectivity of the azinomycins.

LePla RC, Landreau CA, Shipman M, Jones GD. LePla RC, et al. Org Biomol Chem. 2005 Apr 7;3(7):1174-5. doi: 10.1039/b502188j. Epub 2005 Mar 1. Org Biomol Chem. 2005. PMID: 15785803

9

Delineating noncovalent interactions between the azinomycins and double-stranded DNA: importance of the naphthalene substitution pattern on interstrand cross-linking efficiency.

Landreau CA, LePla RC, Shipman M, Slawin AM, Hartley JA. Landreau CA, et al. Org Lett. 2004 Sep 30;6(20):3505-7. doi: 10.1021/ol048653y. Org Lett. 2004. PMID: 15387534

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