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Page 1
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS. Holash J, et al. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11393-8. doi: 10.1073/pnas.172398299. Epub 2002 Aug 12. Proc Natl Acad Sci U S A. 2002. PMID: 12177445 Free PMC article.
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD. Rudge JS, et al. Among authors: holash j. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18363-70. doi: 10.1073/pnas.0708865104. Epub 2007 Nov 13. Proc Natl Acad Sci U S A. 2007. PMID: 18000042 Free PMC article.
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma.
Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Kim ES, et al. Among authors: holash j. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11399-404. doi: 10.1073/pnas.172398399. Epub 2002 Aug 12. Proc Natl Acad Sci U S A. 2002. PMID: 12177446 Free PMC article.
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade.
Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O'Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Huang J, et al. Among authors: holash j. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7785-90. doi: 10.1073/pnas.1432908100. Epub 2003 Jun 12. Proc Natl Acad Sci U S A. 2003. PMID: 12805568 Free PMC article.
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD. Gale NW, et al. Among authors: holash j. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54. doi: 10.1073/pnas.0407290101. Epub 2004 Nov 1. Proc Natl Acad Sci U S A. 2004. PMID: 15520367 Free PMC article.
Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation.
Kadenhe-Chiweshe A, Papa J, McCrudden KW, Frischer J, Bae JO, Huang J, Fisher J, Lefkowitch JH, Feirt N, Rudge J, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Kadenhe-Chiweshe A, et al. Among authors: holash j. Mol Cancer Res. 2008 Jan;6(1):1-9. doi: 10.1158/1541-7786.MCR-07-0101. Mol Cancer Res. 2008. PMID: 18234958 Free article.
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Huang J, Frischer JS, New T, Kim ES, Serur A, Lee A, Kadenhe-Chiwishe A, Pollyea DA, Yokoi A, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Huang J, et al. Among authors: holash j. Mol Cancer Ther. 2004 Mar;3(3):335-43. Mol Cancer Ther. 2004. PMID: 15026554
48 results