Beaumont KC - Search Results

1

A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.

Allerton CM, Barber CG, Beaumont KC, Brown DG, Cole SM, Ellis D, Lane CA, Maw GN, Mount NM, Rawson DJ, Robinson CM, Street SD, Summerhill NW. Allerton CM, et al. Among authors: beaumont kc. J Med Chem. 2006 Jun 15;49(12):3581-94. doi: 10.1021/jm060113e. J Med Chem. 2006. PMID: 16759100

2

Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.

Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K, Evans K, Gray AJ, Holland SJ, Feeder N, Moore RS, Brown DG. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103. doi: 10.1021/jm0702433. Epub 2007 Nov 9. J Med Chem. 2007. PMID: 17990866

3

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.

Rawson DJ, Ballard S, Barber C, Barker L, Beaumont K, Bunnage M, Cole S, Corless M, Denton S, Ellis D, Floc'h M, Foster L, Gosset J, Holmwood F, Lane C, Leahy D, Mathias J, Maw G, Million W, Poinsard C, Price J, Russel R, Street S, Watson L. Rawson DJ, et al. Bioorg Med Chem. 2012 Jan 1;20(1):498-509. doi: 10.1016/j.bmc.2011.10.022. Epub 2011 Oct 24. Bioorg Med Chem. 2012. PMID: 22100260

4

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.

Pryde DC, Maw GN, Planken S, Platts MY, Sanderson V, Corless M, Stobie A, Barber CG, Russell R, Foster L, Barker L, Wayman C, Van Der Graaf P, Stacey P, Morren D, Kohl C, Beaumont K, Coggon S, Tute M. Pryde DC, et al. J Med Chem. 2006 Jul 13;49(14):4409-24. doi: 10.1021/jm060133g. J Med Chem. 2006. PMID: 16821800

5

The discovery of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalized glutaramides.

Maw GN, Stobie A, Planken S, Pryde DC, Sanderson V, Platts MY, Corless M, Stacey P, Wayman C, Van Der Graaf P, Kohl C, Coggon S, Beaumont K. Maw GN, et al. Chem Biol Drug Des. 2006 Jan;67(1):74-7. doi: 10.1111/j.1747-0285.2005.00320.x. Chem Biol Drug Des. 2006. PMID: 16492151

6

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.

Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD. Andrews MD, et al. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24. doi: 10.1021/ml500479v. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893043 Free PMC article.

7

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.

Pryde DC, Cook AS, Burring DJ, Jones LH, Foll S, Platts MY, Sanderson V, Corless M, Stobie A, Middleton DS, Foster L, Barker L, Van Der Graaf P, Stacey P, Kohl C, Coggon S, Beaumont K. Pryde DC, et al. Bioorg Med Chem. 2007 Jan 1;15(1):142-59. doi: 10.1016/j.bmc.2006.10.002. Epub 2006 Oct 6. Bioorg Med Chem. 2007. PMID: 17070062

8

Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog.

Walker DK, Beaumont KC, Comby P, Evans KM, Gedge JI, Halliday RC, Roffey SJ, Wright PA. Walker DK, et al. Among authors: beaumont kc. Xenobiotica. 2001 Aug-Sep;31(8-9):651-64. doi: 10.1080/00498250110056522. Xenobiotica. 2001. PMID: 11569531

9

Small, non-peptide C5a receptor antagonists: part 2.

Blagg J, Mowbray C, Pryde D, Salmon G, Fairman D, Schmid E, Beaumont K. Blagg J, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5605-8. doi: 10.1016/j.bmcl.2008.08.101. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18804369

10

Dose Predictions for Drug Design.

Maurer TS, Smith D, Beaumont K, Di L. Maurer TS, et al. J Med Chem. 2020 Jun 25;63(12):6423-6435. doi: 10.1021/acs.jmedchem.9b01365. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31913040

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