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Page 1
Piperidine-renin inhibitors compounds with improved physicochemical properties.
Güller R, Binggeli A, Breu V, Bur D, Fischli W, Hirth G, Jenny C, Kansy M, Montavon F, Müller M, Oefner C, Stadler H, Vieira E, Wilhelm M, Wostl W, Märki HP. Güller R, et al. Among authors: marki hp. Bioorg Med Chem Lett. 1999 May 17;9(10):1403-8. doi: 10.1016/s0960-894x(99)00196-1. Bioorg Med Chem Lett. 1999. PMID: 10360745
Piperidine renin inhibitors: from leads to drug candidates.
Märki HP, Binggeli A, Bittner B, Bohner-Lang V, Breu V, Bur D, Coassolo PH, Clozel JP, D'Arcy A, Doebeli H, Fischli W, Funk CH, Foricher J, Giller T, Grüninger F, Guenzi A, Güller R, Hartung T, Hirth G, Jenny CH, Kansy M, Klinkhammer U, Lave T, Lohri B, Luft FC, Mervaala EM, Müller DN, Müller M, Montavon F, Oefner CH, Qiu C, Reichel A, Sanwald-Ducray P, Scalone M, Schleimer M, Schmid R, Stadler H, Treiber A, Valdenaire O, Vieira E, Waldmeier P, Wiegand-Chou R, Wilhelm M, Wostl W, Zell M, Zell R. Märki HP, et al. Farmaco. 2001 Jan-Feb;56(1-2):21-7. doi: 10.1016/s0014-827x(01)01004-7. Farmaco. 2001. PMID: 11347960
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.
Burgermeister E, Schnoebelen A, Flament A, Benz J, Stihle M, Gsell B, Rufer A, Ruf A, Kuhn B, Märki HP, Mizrahi J, Sebokova E, Niesor E, Meyer M. Burgermeister E, et al. Among authors: marki hp. Mol Endocrinol. 2006 Apr;20(4):809-30. doi: 10.1210/me.2005-0171. Epub 2005 Dec 22. Mol Endocrinol. 2006. PMID: 16373399
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Martin RE, Aebi JD, Hornsperger B, Krebs HJ, Kuhn B, Kuglstatter A, Alker AM, Märki HP, Müller S, Burger D, Ottaviani G, Riboulet W, Verry P, Tan X, Amrein K, Mayweg AV. Martin RE, et al. Among authors: marki hp. J Med Chem. 2015 Oct 22;58(20):8054-65. doi: 10.1021/acs.jmedchem.5b00851. Epub 2015 Oct 2. J Med Chem. 2015. PMID: 26403853
18 results