Francis SH - Search Results

1

Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.

Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Wang H, et al. Among authors: francis sh. J Biol Chem. 2006 Jul 28;281(30):21469-21479. doi: 10.1074/jbc.M512527200. Epub 2006 May 30. J Biol Chem. 2006. PMID: 16735511 Free article.

2

Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity.

Francis SH, Bessay EP, Kotera J, Grimes KA, Liu L, Thompson WJ, Corbin JD. Francis SH, et al. J Biol Chem. 2002 Dec 6;277(49):47581-7. doi: 10.1074/jbc.M206088200. Epub 2002 Sep 30. J Biol Chem. 2002. PMID: 12359732 Free article.

3

Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.

Richie-Jannetta R, Francis SH, Corbin JD. Richie-Jannetta R, et al. Among authors: francis sh. J Biol Chem. 2003 Dec 12;278(50):50070-9. doi: 10.1074/jbc.M306796200. Epub 2003 Aug 21. J Biol Chem. 2003. PMID: 12933804 Free article.

4

Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists.

Francis SH, Corbin JD. Francis SH, et al. Curr Urol Rep. 2003 Dec;4(6):457-65. doi: 10.1007/s11934-003-0027-x. Curr Urol Rep. 2003. PMID: 14622499 Review.

5

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.

Huai Q, Liu Y, Francis SH, Corbin JD, Ke H. Huai Q, et al. Among authors: francis sh. J Biol Chem. 2004 Mar 26;279(13):13095-101. doi: 10.1074/jbc.M311556200. Epub 2003 Dec 10. J Biol Chem. 2004. PMID: 14668322 Free article.

6

Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation.

Zoraghi R, Bessay EP, Corbin JD, Francis SH. Zoraghi R, et al. Among authors: francis sh. J Biol Chem. 2005 Mar 25;280(12):12051-63. doi: 10.1074/jbc.M413611200. Epub 2005 Jan 27. J Biol Chem. 2005. PMID: 15677448 Free article.

7

Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.

Zoraghi R, Corbin JD, Francis SH. Zoraghi R, et al. Among authors: francis sh. J Biol Chem. 2006 Mar 3;281(9):5553-8. doi: 10.1074/jbc.M510372200. Epub 2006 Jan 5. J Biol Chem. 2006. PMID: 16407275 Free article.

8

Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.

Wang H, Ye M, Robinson H, Francis SH, Ke H. Wang H, et al. Among authors: francis sh. Mol Pharmacol. 2008 Jan;73(1):104-10. doi: 10.1124/mol.107.040212. Epub 2007 Oct 24. Mol Pharmacol. 2008. PMID: 17959709 Free PMC article.

9

Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.

Zoraghi R, Francis SH, Corbin JD. Zoraghi R, et al. Among authors: francis sh. Biochemistry. 2007 Nov 27;46(47):13554-63. doi: 10.1021/bi7010702. Epub 2007 Nov 3. Biochemistry. 2007. PMID: 17979301

10

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

Thomas MK, Francis SH, Corbin JD. Thomas MK, et al. Among authors: francis sh. J Biol Chem. 1990 Sep 5;265(25):14964-70. J Biol Chem. 1990. PMID: 1697584 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

142 results

Search Page

Filters