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P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V. Arasappan A, et al. Among authors: butkiewicz n. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. doi: 10.1016/j.bmcl.2006.05.022. Epub 2006 May 30. Bioorg Med Chem Lett. 2006. PMID: 16730985
Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.
Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Arasappan A, et al. Among authors: butkiewicz n. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. doi: 10.1016/j.bmcl.2004.09.058. Bioorg Med Chem Lett. 2004. PMID: 15501035
Novel inhibitors of the hepatitis C virus NS3 proteinase.
Bennett F, Liu YT, Saksena AK, Arasappan A, Butkiewicz N, Dasmahapatra B, Pichardo JS, Njoroge FG, Patel NM, Huang Y, Yang X. Bennett F, et al. Among authors: butkiewicz n. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4275-8. doi: 10.1016/j.bmcl.2005.06.079. Bioorg Med Chem Lett. 2005. PMID: 16087334
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
Venkatraman S, Bogen SL, Arasappan A, Bennett F, Chen K, Jao E, Liu YT, Lovey R, Hendrata S, Huang Y, Pan W, Parekh T, Pinto P, Popov V, Pike R, Ruan S, Santhanam B, Vibulbhan B, Wu W, Yang W, Kong J, Liang X, Wong J, Liu R, Butkiewicz N, Chase R, Hart A, Agrawal S, Ingravallo P, Pichardo J, Kong R, Baroudy B, Malcolm B, Guo Z, Prongay A, Madison V, Broske L, Cui X, Cheng KC, Hsieh Y, Brisson JM, Prelusky D, Korfmacher W, White R, Bogdanowich-Knipp S, Pavlovsky A, Bradley P, Saksena AK, Ganguly A, Piwinski J, Girijavallabhan V, Njoroge FG. Venkatraman S, et al. Among authors: butkiewicz n. J Med Chem. 2006 Oct 5;49(20):6074-86. doi: 10.1021/jm060325b. J Med Chem. 2006. PMID: 17004721
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