Chen T - Search Results

1

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.

Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K, Rodrigues AD. Sinz M, et al. Among authors: chen t. Curr Drug Metab. 2006 May;7(4):375-88. doi: 10.2174/138920006776873535. Curr Drug Metab. 2006. PMID: 16724927

2

Coactivators in assay design for nuclear hormone receptor drug discovery.

Chen T, Xie W, Agler M, Banks M. Chen T, et al. Assay Drug Dev Technol. 2003 Dec;1(6):835-42. doi: 10.1089/154065803772613462. Assay Drug Dev Technol. 2003. PMID: 15090229 Review.

3

Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays.

Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K. Zhu Z, et al. Among authors: chen t. J Biomol Screen. 2004 Sep;9(6):533-40. doi: 10.1177/1087057104264902. J Biomol Screen. 2004. PMID: 15452340

4

Analysis of cellular events using CellCard System in cell-based high-content multiplexed assays.

Chen T, Hansen G, Beske O, Yates K, Zhu Y, Anthony M, Agler M, Banks M. Chen T, et al. Expert Rev Mol Diagn. 2005 Sep;5(5):817-29. doi: 10.1586/14737159.5.5.817. Expert Rev Mol Diagn. 2005. PMID: 16149883

5

Animal models of xenobiotic receptors in drug metabolism and diseases.

Gong H, Sinz MW, Feng Y, Chen T, Venkataramanan R, Xie W. Gong H, et al. Among authors: chen t. Methods Enzymol. 2005;400:598-618. doi: 10.1016/S0076-6879(05)00034-0. Methods Enzymol. 2005. PMID: 16399373 Review.

6

Multiplexing a high-throughput liability assay to leverage efficiencies.

Herbst J, Anthony M, Stewart J, Connors D, Chen T, Banks M, Petrillo EW, Agler M. Herbst J, et al. Among authors: chen t. Assay Drug Dev Technol. 2009 Jun;7(3):294-303. doi: 10.1089/adt.2008.184. Assay Drug Dev Technol. 2009. PMID: 19530896

7

Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

Pondugula SR, Tong AA, Wu J, Cui J, Chen T. Pondugula SR, et al. Among authors: chen t. Drug Metab Dispos. 2010 Sep;38(9):1411-6. doi: 10.1124/dmd.110.032128. Epub 2010 Jun 10. Drug Metab Dispos. 2010. PMID: 20538721 Free PMC article.

8

Pregnane X receptor and drug-induced liver injury.

Wang YM, Chai SC, Brewer CT, Chen T. Wang YM, et al. Among authors: chen t. Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1521-32. doi: 10.1517/17425255.2014.963555. Epub 2014 Sep 25. Expert Opin Drug Metab Toxicol. 2014. PMID: 25252616 Free PMC article. Review.

9

Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery.

Lolodi O, Wang YM, Wright WC, Chen T. Lolodi O, et al. Among authors: chen t. Curr Drug Metab. 2017;18(12):1095-1105. doi: 10.2174/1389200218666170531112038. Curr Drug Metab. 2017. PMID: 28558634 Free PMC article. Review.

10

High throughput screening identified a substituted imidazole as a novel RANK pathway-selective osteoclastogenesis inhibitor.

Chen T, Knapp AC, Wu Y, Huang J, Lynch JS, Dickson JK Jr, Lawrence RM, Feyen JH, Agler ML. Chen T, et al. Assay Drug Dev Technol. 2006 Aug;4(4):387-96. doi: 10.1089/adt.2006.4.387. Assay Drug Dev Technol. 2006. PMID: 16945012

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