Peach ML - Search Results

1

Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.

Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: peach ml. J Med Chem. 2006 Jun 1;49(11):3185-203. doi: 10.1021/jm060011o. J Med Chem. 2006. PMID: 16722637

2

Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain.

Li P, Peach ML, Zhang M, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Mar 10;13(5):895-9. doi: 10.1016/s0960-894x(03)00015-5. Bioorg Med Chem Lett. 2003. PMID: 12617916

3

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Sigano DM, et al. Among authors: peach ml. J Med Chem. 2003 Apr 24;46(9):1571-9. doi: 10.1021/jm020476o. J Med Chem. 2003. PMID: 12699375

4

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Li P, Zhang M, Long YQ, Peach ML, Liu H, Yang D, Nicklaus M, Roller PP. Li P, et al. Among authors: peach ml. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2173-7. doi: 10.1016/s0960-894x(03)00385-8. Bioorg Med Chem Lett. 2003. PMID: 12798329

5

Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE. Tamamura H, et al. Among authors: peach ml. J Med Chem. 2004 Sep 23;47(20):4858-64. doi: 10.1021/jm049723+. J Med Chem. 2004. PMID: 15369389

6

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: peach ml. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

7

Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.

Song YL, Peach ML, Roller PP, Qiu S, Wang S, Long YQ. Song YL, et al. Among authors: peach ml. J Med Chem. 2006 Mar 9;49(5):1585-96. doi: 10.1021/jm050910x. J Med Chem. 2006. PMID: 16509576

8

Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms.

Pu Y, Peach ML, Garfield SH, Wincovitch S, Marquez VE, Blumberg PM. Pu Y, et al. Among authors: peach ml. J Biol Chem. 2006 Nov 3;281(44):33773-88. doi: 10.1074/jbc.M606560200. Epub 2006 Sep 1. J Biol Chem. 2006. PMID: 16950780 Free article.

9

Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.

Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE. Choi Y, et al. Among authors: peach ml. J Med Chem. 2007 Jul 26;50(15):3465-81. doi: 10.1021/jm0702579. Epub 2007 Jun 26. J Med Chem. 2007. PMID: 17591763

10

Wealth of opportunity - the C1 domain as a target for drug development.

Blumberg PM, Kedei N, Lewin NE, Yang D, Czifra G, Pu Y, Peach ML, Marquez VE. Blumberg PM, et al. Among authors: peach ml. Curr Drug Targets. 2008 Aug;9(8):641-52. doi: 10.2174/138945008785132376. Curr Drug Targets. 2008. PMID: 18691011 Free PMC article. Review.

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