Benzaria S - Search Results

1

Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.

Kang JH, Benzaria S, Sigano DM, Lewin NE, Pu Y, Peach ML, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: benzaria s. J Med Chem. 2006 Jun 1;49(11):3185-203. doi: 10.1021/jm060011o. J Med Chem. 2006. PMID: 16722637

2

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).

Benzaria S, Bienfait B, Nacro K, Wang S, Lewin NE, Beheshti M, Blumberg PM, Marquez VE. Benzaria S, et al. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3403-8. doi: 10.1016/s0960-894x(98)00614-3. Bioorg Med Chem Lett. 1998. PMID: 9873742

3

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Nacro K, Bienfait B, Lee J, Han KC, Kang JH, Benzaria S, Lewin NE, Bhattacharyya DK, Blumberg PM, Marquez VE. Nacro K, et al. Among authors: benzaria s. J Med Chem. 2000 Mar 9;43(5):921-44. doi: 10.1021/jm9904607. J Med Chem. 2000. PMID: 10715158

4

Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.

Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE. Lee J, et al. Among authors: benzaria s. J Med Chem. 2001 Dec 6;44(25):4309-12. doi: 10.1021/jm0103965. J Med Chem. 2001. PMID: 11728178

5

The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.

Marquez VE, Nacro K, Benzaria S, Lee J, Sharma R, Teng K, Milne GW, Bienfait B, Wang S, Lewin NE, Blumberg PM. Marquez VE, et al. Among authors: benzaria s. Pharmacol Ther. 1999 May-Jun;82(2-3):251-61. doi: 10.1016/s0163-7258(98)00048-5. Pharmacol Ther. 1999. PMID: 10454202 Review.

6

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

Pierra C, Amador A, Benzaria S, Cretton-Scott E, D'Amours M, Mao J, Mathieu S, Moussa A, Bridges EG, Standring DN, Sommadossi JP, Storer R, Gosselin G. Pierra C, et al. Among authors: benzaria s. J Med Chem. 2006 Nov 2;49(22):6614-20. doi: 10.1021/jm0603623. J Med Chem. 2006. PMID: 17064080

7

Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.

Benzaria S, Pélicano H, Johnson R, Maury G, Imbach JL, Aubertin AM, Obert G, Gosselin G. Benzaria S, et al. J Med Chem. 1996 Dec 6;39(25):4958-65. doi: 10.1021/jm960289o. J Med Chem. 1996. PMID: 8960556

8

Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of beta-L-2'-deoxycytidine, a selective and specific anti-HBV agent.

Pierra C, Benzaria S, Dukhan D, Loi AG, La Colla P, Bridges E, Mao J, Standring D, Sommadossi JP, Gosselin G. Pierra C, et al. Among authors: benzaria s. Antivir Chem Chemother. 2004 Sep;15(5):269-79. doi: 10.1177/095632020401500506. Antivir Chem Chemother. 2004. PMID: 15535049 Free article.

9

2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.

Benzaria S, Bardiot D, Bouisset T, Counor C, Rabeson C, Pierra C, Storer R, Loi AG, Cadeddu A, Mura M, Musiu C, Liuzzi M, Loddo R, Bergelson S, Bichko V, Bridges E, Cretton-Scott E, Mao J, Sommadossi JP, Seifer M, Standring D, Tausek M, Gosselin G, La Colla P. Benzaria S, et al. Antivir Chem Chemother. 2007;18(4):225-42. doi: 10.1177/095632020701800406. Antivir Chem Chemother. 2007. PMID: 17907380 Free article.

10

Monoval-LdC: efficient prodrug of 2'-deoxy-beta-L-cytidine (L-dC), a potent and selective anti-HBV agent.

Benzaria S, Pierra C, Bardiot D, Cretton-Scott E, Bridges EG, Zhou XJ, Standring D, Gosselin G. Benzaria S, et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1003-6. doi: 10.1081/NCN-120022723. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565331

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