Zhen J - Search Results

1

The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins.

Reith ME, Zhen J, Chen N. Reith ME, et al. Among authors: zhen j. Handb Exp Pharmacol. 2006;(175):75-93. doi: 10.1007/3-540-29784-7_4. Handb Exp Pharmacol. 2006. PMID: 16722231 Review.

2

Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.

Zhen J, Maiti S, Chen N, Dutta AK, Reith ME. Zhen J, et al. Eur J Pharmacol. 2004 Dec 3;506(1):17-26. doi: 10.1016/j.ejphar.2004.10.028. Eur J Pharmacol. 2004. PMID: 15588620

3

Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates.

Zhen J, Chen N, Reith ME. Zhen J, et al. Neuropharmacology. 2005 Nov;49(6):769-79. doi: 10.1016/j.neuropharm.2005.07.002. Epub 2005 Aug 24. Neuropharmacology. 2005. PMID: 16122767

4

Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.

Chen N, Zhen J, Reith ME. Chen N, et al. Among authors: zhen j. J Neurochem. 2004 May;89(4):853-64. doi: 10.1111/j.1471-4159.2004.02386.x. J Neurochem. 2004. PMID: 15140185 Free article.

5

Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters.

Zhang S, Zhen J, Reith ME, Dutta AK. Zhang S, et al. Among authors: zhen j. Bioorg Med Chem. 2004 Dec 1;12(23):6301-15. doi: 10.1016/j.bmc.2004.07.069. Bioorg Med Chem. 2004. PMID: 15519172

6

Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.

Zhang S, Zhen J, Reith ME, Dutta AK. Zhang S, et al. Among authors: zhen j. J Med Chem. 2005 Jul 28;48(15):4962-71. doi: 10.1021/jm049021k. J Med Chem. 2005. PMID: 16033275

7

Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine.

Zhang S, Zhen J, Reith ME, Dutta AK. Zhang S, et al. Among authors: zhen j. Bioorg Med Chem. 2006 Jun 1;14(11):3953-66. doi: 10.1016/j.bmc.2006.01.051. Epub 2006 Feb 14. Bioorg Med Chem. 2006. PMID: 16481172

8

Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.

Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Zhang S, et al. Among authors: zhen j. J Med Chem. 2006 Jul 13;49(14):4239-47. doi: 10.1021/jm0601699. J Med Chem. 2006. PMID: 16821783

9

Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.

Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Mishra M, et al. Among authors: zhen j. Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. doi: 10.1016/j.bmc.2008.01.009. Epub 2008 Jan 11. Bioorg Med Chem. 2008. PMID: 18249549 Free PMC article.

10

Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.

Liang YJ, Zhen J, Chen N, Reith ME. Liang YJ, et al. Among authors: zhen j. J Neurochem. 2009 May;109(4):981-94. doi: 10.1111/j.1471-4159.2009.06034.x. Epub 2009 Mar 11. J Neurochem. 2009. PMID: 19519772 Free PMC article.

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