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Supersaturation produces high bioavailability of amorphous danazol particles formed by evaporative precipitation into aqueous solution and spray freezing into liquid technologies.

Vaughn JM, McConville JT, Crisp MT, Johnston KP, Williams RO 3rd. Vaughn JM, et al. Among authors: crisp mt. Drug Dev Ind Pharm. 2006 Jun;32(5):559-67. doi: 10.1080/03639040500529176. Drug Dev Ind Pharm. 2006. PMID: 16720411

Rapidly dissolving repaglinide powders produced by the ultra-rapid freezing process.

Purvis T, Mattucci ME, Crisp MT, Johnston KP, Williams RO 3rd. Purvis T, et al. Among authors: crisp mt. AAPS PharmSciTech. 2007 Jul 20;8(3):E58. doi: 10.1208/pt0803058. AAPS PharmSciTech. 2007. PMID: 17915808

Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals.

Crisp MT, Tucker CJ, Rogers TL, Williams RO 3rd, Johnston KP. Crisp MT, et al. J Control Release. 2007 Feb 26;117(3):351-9. doi: 10.1016/j.jconrel.2006.11.011. Epub 2006 Nov 17. J Control Release. 2007. PMID: 17239469

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