Sweatman TW - Search Results

1

N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx.

Lothstein L, Savranskaya L, Barrett CM, Israel M, Sweatman TW. Lothstein L, et al. Among authors: sweatman tw. Anticancer Drugs. 2006 Jun;17(5):495-502. doi: 10.1097/00001813-200606000-00002. Anticancer Drugs. 2006. PMID: 16702805

2

N-benzyladriamycin-14-valerate (AD198) induces apoptosis through protein kinase C-delta-induced phosphorylation of phospholipid scramblase 3.

He Y, Liu J, Durrant D, Yang HS, Sweatman T, Lothstein L, Lee RM. He Y, et al. Cancer Res. 2005 Nov 1;65(21):10016-23. doi: 10.1158/0008-5472.CAN-05-1688. Cancer Res. 2005. PMID: 16267027

3

Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis.

Barrett CM, Lewis FL, Roaten JB, Sweatman TW, Israel M, Cleveland JL, Lothstein L. Barrett CM, et al. Among authors: sweatman tw. Mol Cancer Ther. 2002 May;1(7):469-81. Mol Cancer Ther. 2002. PMID: 12479265

4

Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity.

Roaten JB, Kazanietz MG, Caloca MJ, Bertics PJ, Lothstein L, Parrill AL, Israel M, Sweatman TW. Roaten JB, et al. Among authors: sweatman tw. Mol Cancer Ther. 2002 May;1(7):483-92. Mol Cancer Ther. 2002. PMID: 12479266

5

N-Benzyladriamycin-14-valerate (AD 198) cytotoxicty circumvents Bcr-Abl anti-apoptotic signaling in human leukemia cells and also potentiates imatinib cytotoxicity.

Lothstein L, Savranskaya L, Sweatman TW. Lothstein L, et al. Among authors: sweatman tw. Leuk Res. 2007 Aug;31(8):1085-95. doi: 10.1016/j.leukres.2006.11.003. Epub 2006 Dec 21. Leuk Res. 2007. PMID: 17187856

6

N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC-epsilon activation.

Hofmann PA, Israel M, Koseki Y, Laskin J, Gray J, Janik A, Sweatman TW, Lothstein L. Hofmann PA, et al. Among authors: sweatman tw. J Pharmacol Exp Ther. 2007 Nov;323(2):658-64. doi: 10.1124/jpet.107.126110. Epub 2007 Aug 10. J Pharmacol Exp Ther. 2007. PMID: 17693586

7

Resistance to N-benzyladriamycin-14-valerate in mouse J774.2 cells: P-glycoprotein expression without reduced N-benzyladriamycin-14-valerate accumulation.

Lothstein L, Sweatman TW, Dockter ME, Israel M. Lothstein L, et al. Among authors: sweatman tw. Cancer Res. 1992 Jun 15;52(12):3409-17. Cancer Res. 1992. PMID: 1350753

8

P-glycoprotein overexpression in mouse cells does not correlate with resistance to N-benzyladriamycin-14-valerate (AD 198).

Lothstein L, Koseki Y, Sweatman TW. Lothstein L, et al. Among authors: sweatman tw. Anticancer Drugs. 1994 Dec;5(6):623-33. doi: 10.1097/00001813-199412000-00003. Anticancer Drugs. 1994. PMID: 7888699

9

Cytotoxicity and intracellular biotransformation of N-benzyladriamycin-14-valerate (AD 198) are modulated by changes in 14-O-acyl chain length.

Lothstein L, Rodrigues PJ, Sweatman TW, Israel M. Lothstein L, et al. Among authors: sweatman tw. Anticancer Drugs. 1998 Jan;9(1):58-66. doi: 10.1097/00001813-199801000-00007. Anticancer Drugs. 1998. PMID: 9491793

10

Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta.

Roaten JB, Kazanietz MG, Sweatman TW, Lothstein L, Israel M, Parrill AL. Roaten JB, et al. Among authors: sweatman tw. J Med Chem. 2001 Mar 29;44(7):1028-34. doi: 10.1021/jm000289v. J Med Chem. 2001. PMID: 11297449

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