Martoglio B - Search Results

1

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.

Dev KK, Chatterjee S, Osinde M, Stauffer D, Morgan H, Kobialko M, Dengler U, Rueeger H, Martoglio B, Rovelli G. Dev KK, et al. Among authors: martoglio b. Eur J Pharmacol. 2006 Jul 1;540(1-3):10-7. doi: 10.1016/j.ejphar.2006.04.011. Epub 2006 Apr 15. Eur J Pharmacol. 2006. PMID: 16697367

2

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.

Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B. Weihofen A, et al. Among authors: martoglio b. J Biol Chem. 2003 May 9;278(19):16528-33. doi: 10.1074/jbc.M301372200. Epub 2003 Mar 5. J Biol Chem. 2003. PMID: 12621027 Free article.

3

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B. Friedmann E, et al. Among authors: martoglio b. J Biol Chem. 2004 Dec 3;279(49):50790-8. doi: 10.1074/jbc.M407898200. Epub 2004 Sep 21. J Biol Chem. 2004. PMID: 15385547 Free article.

4

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.

Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B. Friedmann E, et al. Among authors: martoglio b. Nat Cell Biol. 2006 Aug;8(8):843-8. doi: 10.1038/ncb1440. Epub 2006 Jul 9. Nat Cell Biol. 2006. PMID: 16829952

5

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.

Weihofen A, Lemberg MK, Ploegh HL, Bogyo M, Martoglio B. Weihofen A, et al. Among authors: martoglio b. J Biol Chem. 2000 Oct 6;275(40):30951-6. doi: 10.1074/jbc.M005980200. J Biol Chem. 2000. PMID: 10921927 Free article.

6

Identification of signal peptide peptidase, a presenilin-type aspartic protease.

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B. Weihofen A, et al. Among authors: martoglio b. Science. 2002 Jun 21;296(5576):2215-8. doi: 10.1126/science.1070925. Science. 2002. PMID: 12077416

7

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis.

Lemberg MK, Martoglio B. Lemberg MK, et al. Among authors: martoglio b. Mol Cell. 2002 Oct;10(4):735-44. doi: 10.1016/s1097-2765(02)00655-x. Mol Cell. 2002. PMID: 12419218 Free article.

8

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.

Martoglio B, Golde TE. Martoglio B, et al. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R201-6. doi: 10.1093/hmg/ddg303. Epub 2003 Sep 9. Hum Mol Genet. 2003. PMID: 12966028 Review.

9

Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase.

Heimann M, Roman-Sosa G, Martoglio B, Thiel HJ, Rümenapf T. Heimann M, et al. Among authors: martoglio b. J Virol. 2006 Feb;80(4):1915-21. doi: 10.1128/JVI.80.4.1915-1921.2006. J Virol. 2006. PMID: 16439547 Free PMC article.

10

Aspartic proteases in drug discovery.

Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B. Eder J, et al. Among authors: martoglio b. Curr Pharm Des. 2007;13(3):271-85. doi: 10.2174/138161207779313560. Curr Pharm Des. 2007. PMID: 17313361 Review.

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