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Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. Esposito L, et al. Among authors: puolivali j. J Neurosci. 2006 May 10;26(19):5167-79. doi: 10.1523/JNEUROSCI.0482-06.2006. J Neurosci. 2006. PMID: 16687508 Free PMC article.
The radical scavenger IAC (bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decantionate) decreases mortality, enhances cognitive functions in water maze and reduces amyloid plaque burden in hAβPP transgenic mice.
Puoliväli J, Nurmi A, Miettinen TK, Soleti A, Riccardino F, Kalesnykas G, Heikkinen T, Vartiainen N, Pussinen R, Tähtivaara L, Lehtimäki K, Yrjänheikki J, Canistro D, Sapone A, Spisni E, Paolini M. Puoliväli J, et al. J Alzheimers Dis. 2011;27(3):499-510. doi: 10.3233/JAD-2011-110881. J Alzheimers Dis. 2011. PMID: 21821875
mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
Colton CA, Wilson JG, Everhart A, Wilcock DM, Puoliväli J, Heikkinen T, Oksman J, Jääskeläinen O, Lehtimäki K, Laitinen T, Vartiainen N, Vitek MP. Colton CA, et al. Among authors: puolivali j. J Neuropathol Exp Neurol. 2014 Aug;73(8):752-69. doi: 10.1097/NEN.0000000000000094. J Neuropathol Exp Neurol. 2014. PMID: 25003233 Free PMC article.
51 results