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A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.
Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R. Aoki K, et al. Among authors: takahashi m. J Clin Invest. 2006 Jun;116(6):1525-34. doi: 10.1172/JCI22513. Epub 2006 May 4. J Clin Invest. 2006. PMID: 16680194 Free PMC article.
The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study.
Kato G, Shimizu Y, Arai Y, Suzuki N, Sugamori Y, Maeda M, Takahashi M, Tamura Y, Wakabayashi N, Murali R, Ono T, Ohya K, Mise-Omata S, Aoki K. Kato G, et al. Among authors: takahashi m. Arthritis Res Ther. 2015 Sep 12;17(1):251. doi: 10.1186/s13075-015-0753-8. Arthritis Res Ther. 2015. PMID: 26373710 Free PMC article.
p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.
Nagai Y, Osawa K, Fukushima H, Tamura Y, Aoki K, Ohya K, Yasuda H, Hikiji H, Takahashi M, Seta Y, Seo S, Kurokawa M, Kato S, Honda H, Nakamura I, Maki K, Jimi E. Nagai Y, et al. Among authors: takahashi m. J Bone Miner Res. 2013 Dec;28(12):2449-62. doi: 10.1002/jbmr.1936. J Bone Miner Res. 2013. PMID: 23526406 Free article.
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