Kuntz ID - Search Results

1

Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors.

Lu F, Chi SW, Kim DH, Han KH, Kuntz ID, Guy RK. Lu F, et al. Among authors: kuntz id. J Comb Chem. 2006 May-Jun;8(3):315-25. doi: 10.1021/cc050142v. J Comb Chem. 2006. PMID: 16677000

2

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

Greenbaum DC, Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M. Greenbaum DC, et al. Among authors: kuntz id. Chem Biol. 2002 Oct;9(10):1085-94. doi: 10.1016/s1074-5521(02)00238-7. Chem Biol. 2002. PMID: 12401493

3

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

Fujii N, Haresco JJ, Novak KA, Gage RM, Pedemonte N, Stokoe D, Kuntz ID, Guy RK. Fujii N, et al. Among authors: kuntz id. Bioorg Med Chem Lett. 2007 Jan 15;17(2):549-52. doi: 10.1016/j.bmcl.2006.10.006. Epub 2006 Oct 6. Bioorg Med Chem Lett. 2007. PMID: 17055267

4

A selective irreversible inhibitor targeting a PDZ protein interaction domain.

Fujii N, Haresco JJ, Novak KA, Stokoe D, Kuntz ID, Guy RK. Fujii N, et al. Among authors: kuntz id. J Am Chem Soc. 2003 Oct 8;125(40):12074-5. doi: 10.1021/ja035540l. J Am Chem Soc. 2003. PMID: 14518976

5

Partial acetylation of lysine residues improves intraprotein cross-linking.

Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Guo X, et al. Among authors: kuntz id. Anal Chem. 2008 Feb 15;80(4):951-60. doi: 10.1021/ac701636w. Epub 2008 Jan 18. Anal Chem. 2008. PMID: 18201069

6

Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes.

Verras A, Kuntz ID, Ortiz de Montellano PR. Verras A, et al. Among authors: kuntz id. J Med Chem. 2004 Jul 1;47(14):3572-9. doi: 10.1021/jm030608t. J Med Chem. 2004. PMID: 15214784

7

Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.

Rutenber E, Fauman EB, Keenan RJ, Fong S, Furth PS, Ortiz de Montellano PR, Meng E, Kuntz ID, DeCamp DL, Salto R, et al. Rutenber E, et al. Among authors: kuntz id. J Biol Chem. 1993 Jul 25;268(21):15343-6. J Biol Chem. 1993. PMID: 8340363 Free article.

8

Design, docking, and evaluation of multiple libraries against multiple targets.

Lamb ML, Burdick KW, Toba S, Young MM, Skillman AG, Zou X, Arnold JR, Kuntz ID. Lamb ML, et al. Among authors: kuntz id. Proteins. 2001 Feb 15;42(3):296-318. doi: 10.1002/1097-0134(20010215)42:3<296::aid-prot20>3.0.co;2-f. Proteins. 2001. PMID: 11151003

9

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

Kick EK, Roe DC, Skillman AG, Liu G, Ewing TJ, Sun Y, Kuntz ID, Ellman JA. Kick EK, et al. Among authors: kuntz id. Chem Biol. 1997 Apr;4(4):297-307. doi: 10.1016/s1074-5521(97)90073-9. Chem Biol. 1997. PMID: 9195867

10

Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.

Haque TS, Skillman AG, Lee CE, Habashita H, Gluzman IY, Ewing TJ, Goldberg DE, Kuntz ID, Ellman JA. Haque TS, et al. Among authors: kuntz id. J Med Chem. 1999 Apr 22;42(8):1428-40. doi: 10.1021/jm980641t. J Med Chem. 1999. PMID: 10212129

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