Willoughby D - Search Results

1

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics.

Willoughby D, Wong W, Schaack J, Scott JD, Cooper DM. Willoughby D, et al. EMBO J. 2006 May 17;25(10):2051-61. doi: 10.1038/sj.emboj.7601113. Epub 2006 Apr 27. EMBO J. 2006. PMID: 16642035 Free PMC article.

2

Use of single-cell imaging techniques to assess the regulation of cAMP dynamics.

Willoughby D, Cooper DM. Willoughby D, et al. Biochem Soc Trans. 2006 Aug;34(Pt 4):468-71. doi: 10.1042/BST0340468. Biochem Soc Trans. 2006. PMID: 16856834

3

Live-cell imaging of cAMP dynamics.

Willoughby D, Cooper DM. Willoughby D, et al. Nat Methods. 2008 Jan;5(1):29-36. doi: 10.1038/nmeth1135. Epub 2007 Dec 28. Nat Methods. 2008. PMID: 18165805 Review.

4

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

Willoughby D, Halls ML, Everett KL, Ciruela A, Skroblin P, Klussmann E, Cooper DM. Willoughby D, et al. J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12. J Cell Sci. 2012. PMID: 22976297 Free PMC article.

5

Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH.

Willoughby D, Masada N, Crossthwaite AJ, Ciruela A, Cooper DM. Willoughby D, et al. J Biol Chem. 2005 Sep 2;280(35):30864-72. doi: 10.1074/jbc.M414355200. Epub 2005 Jul 7. J Biol Chem. 2005. PMID: 16002403 Free article.

6

Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP.

Willoughby D, Cooper DM. Willoughby D, et al. J Cell Sci. 2006 Mar 1;119(Pt 5):828-36. doi: 10.1242/jcs.02812. Epub 2006 Feb 14. J Cell Sci. 2006. PMID: 16478784

7

Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.

Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD. Bauman AL, et al. Among authors: willoughby d. Mol Cell. 2006 Sep 15;23(6):925-31. doi: 10.1016/j.molcel.2006.07.025. Mol Cell. 2006. PMID: 16973443 Free PMC article.

8

Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains.

Willoughby D, Cooper DM. Willoughby D, et al. Physiol Rev. 2007 Jul;87(3):965-1010. doi: 10.1152/physrev.00049.2006. Physiol Rev. 2007. PMID: 17615394 Free article. Review.

9

Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.

Willoughby D, Baillie GS, Lynch MJ, Ciruela A, Houslay MD, Cooper DM. Willoughby D, et al. J Biol Chem. 2007 Nov 23;282(47):34235-49. doi: 10.1074/jbc.M706765200. Epub 2007 Sep 13. J Biol Chem. 2007. PMID: 17855344 Free article.

10

Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

Goraya TA, Masada N, Ciruela A, Willoughby D, Clynes MA, Cooper DM. Goraya TA, et al. Among authors: willoughby d. Cell Signal. 2008 Feb;20(2):359-74. doi: 10.1016/j.cellsig.2007.10.024. Cell Signal. 2008. PMID: 18335582

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