Shapiro TA - Search Results

1

Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.

Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH. Paik IH, et al. Among authors: shapiro ta. J Med Chem. 2006 May 4;49(9):2731-4. doi: 10.1021/jm058288w. J Med Chem. 2006. PMID: 16640333

2

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

Posner GH, Wang D, Cumming JN, Oh CH, French AN, Bodley AL, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001. J Med Chem. 1995. PMID: 7608890 No abstract available.

3

Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.

Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Posner GH, et al. Among authors: shapiro ta. Bioorg Med Chem. 1997 Jul;5(7):1257-65. doi: 10.1016/s0968-0896(97)00079-5. Bioorg Med Chem. 1997. PMID: 9377085 Free article.

4

Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1998 Mar 12;41(6):940-51. doi: 10.1021/jm970686e. J Med Chem. 1998. PMID: 9526568

5

Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.

Cumming JN, Wang D, Park SB, Shapiro TA, Posner GH. Cumming JN, et al. Among authors: shapiro ta. J Med Chem. 1998 Mar 12;41(6):952-64. doi: 10.1021/jm970711g. J Med Chem. 1998. PMID: 9526569

6

Antimalarial cyclic peroxy ketals.

Posner GH, O'Dowd H, Ploypradith P, Cumming JN, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1998 Jun 4;41(12):2164-7. doi: 10.1021/jm980088f. J Med Chem. 1998. PMID: 9622557

7

Synthesis and in vitro antimalarial activity of sulfone endoperoxides.

Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Bachi MD, et al. Among authors: shapiro ta. Bioorg Med Chem Lett. 1998 Apr 21;8(8):903-8. doi: 10.1016/s0960-894x(98)00141-3. Bioorg Med Chem Lett. 1998. PMID: 9871509 Free article.

8

Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.

Posner GH, Parker MH, Northrop J, Elias JS, Ploypradith P, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1999 Jan 28;42(2):300-4. doi: 10.1021/jm980529v. J Med Chem. 1999. PMID: 9925735

9

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1999 Oct 21;42(21):4275-80. doi: 10.1021/jm990363d. J Med Chem. 1999. PMID: 10543871

10

Antimalarial sulfide, sulfone, and sulfonamide trioxanes.

Posner GH, Maxwell JP, O'Dowd H, Krasavin M, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. Bioorg Med Chem. 2000 Jun;8(6):1361-70. doi: 10.1016/s0968-0896(00)00079-1. Bioorg Med Chem. 2000. PMID: 10896113 Free article.

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