Nakatani S - Search Results

1

Design and synthesis of novel metalloproteinase inhibitors.

Nakatani S, Ikura M, Yamamoto S, Nishita Y, Itadani S, Habashita H, Sugiura T, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Nakatani S, et al. Bioorg Med Chem. 2006 Aug 1;14(15):5402-22. doi: 10.1016/j.bmc.2006.03.032. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621578

2

Highly potent inhibitors of TNF-alpha production. Part 1: Discovery of chemical leads.

Matsui T, Kondo T, Nishita Y, Itadani S, Nakatani S, Omawari N, Sakai M, Nakazawa S, Ogata A, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: nakatani s. Bioorg Med Chem Lett. 2002 Mar 25;12(6):903-5. doi: 10.1016/s0960-894x(02)00036-7. Bioorg Med Chem Lett. 2002. PMID: 11958990

3

Highly potent inhibitors of TNF-alpha production. Part I: discovery of new chemical leads and their structure-activity relationships.

Matsui T, Kondo T, Nishita Y, Itadani S, Nakatani S, Omawari N, Sakai M, Nakazawa S, Ogata A, Mori H, Terai K, Kamoshima W, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: nakatani s. Bioorg Med Chem. 2002 Dec;10(12):3757-86. doi: 10.1016/s0968-0896(02)00381-4. Bioorg Med Chem. 2002. PMID: 12413832

4

Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-alpha production.

Matsui T, Kondo T, Nakatani S, Omawari N, Sakai M, Mori H, Ogata A, Kato J, Ohno H, Obata T, Nakai H, Toda M. Matsui T, et al. Among authors: nakatani s. Bioorg Med Chem. 2003 Sep 1;11(18):3937-43. doi: 10.1016/s0968-0896(03)00409-7. Bioorg Med Chem. 2003. PMID: 12927854

5

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach.

Takahashi K, Ikura M, Habashita H, Nishizaki M, Sugiura T, Yamamoto S, Nakatani S, Ogawa K, Ohno H, Nakai H, Toda M. Takahashi K, et al. Among authors: nakatani s. Bioorg Med Chem. 2005 Jul 15;13(14):4527-43. doi: 10.1016/j.bmc.2005.04.051. Bioorg Med Chem. 2005. PMID: 15908222

6

Discovery of a new chemical lead for a matrix metalloproteinase inhibitor.

Ikura M, Nakatani S, Yamamoto S, Habashita H, Sugiura T, Takahashi K, Ogawa K, Ohno H, Nakai H, Toda M. Ikura M, et al. Among authors: nakatani s. Bioorg Med Chem. 2006 Jun 15;14(12):4241-52. doi: 10.1016/j.bmc.2006.01.059. Epub 2006 Feb 14. Bioorg Med Chem. 2006. PMID: 16481176

7

Design and synthesis of an orally active matrix metalloproteinase inhibitor.

Yamamoto S, Nakatani S, Ikura M, Sugiura T, Nishita Y, Itadani S, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Yamamoto S, et al. Among authors: nakatani s. Bioorg Med Chem. 2006 Sep 15;14(18):6383-403. doi: 10.1016/j.bmc.2006.05.040. Epub 2006 Jun 9. Bioorg Med Chem. 2006. PMID: 16765051

8

ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model.

Iwaki Y, Ohhata A, Nakatani S, Hisaichi K, Okabe Y, Hiramatsu A, Watanabe T, Yamamoto S, Nishiyama T, Kobayashi J, Hirooka Y, Moriguchi H, Maeda T, Katoh M, Komichi Y, Ota H, Matsumura N, Okada M, Sugiyama T, Saga H, Imagawa A. Iwaki Y, et al. Among authors: nakatani s. ACS Med Chem Lett. 2020 May 14;11(6):1335-1341. doi: 10.1021/acsmedchemlett.0c00200. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551021 Free PMC article.

9

Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV protease inhibitors have high efficacy in mutant HIV.

Nakatani S, Hidaka K, Ami E, Nakahara K, Sato A, Nguyen JT, Hamada Y, Hori Y, Ohnishi N, Nagai A, Kimura T, Hayashi Y, Kiso Y. Nakatani S, et al. J Med Chem. 2008 May 22;51(10):2992-3004. doi: 10.1021/jm701555p. Epub 2008 Apr 22. J Med Chem. 2008. PMID: 18426195

10

Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.

Ami E, Nakahara K, Sato A, Nguyen JT, Hidaka K, Hamada Y, Nakatani S, Kimura T, Hayashi Y, Kiso Y. Ami E, et al. Among authors: nakatani s. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4213-7. doi: 10.1016/j.bmcl.2007.05.039. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17537628

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