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Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Patel HH, et al. Among authors: yokoyama u. FASEB J. 2007 Sep;21(11):2970-9. doi: 10.1096/fj.07-8424com. Epub 2007 Apr 30. FASEB J. 2007. PMID: 17470567
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. Yokoyama U, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6386-91. doi: 10.1073/pnas.0801490105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434542 Free PMC article.
Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning.
Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Tsutsumi YM, et al. Among authors: yokoyama u. Circulation. 2008 Nov 4;118(19):1979-88. doi: 10.1161/CIRCULATIONAHA.108.788331. Epub 2008 Oct 20. Circulation. 2008. PMID: 18936328 Free PMC article.
cAMP and Epac in the regulation of tissue fibrosis.
Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. Insel PA, et al. Among authors: yokoyama u. Br J Pharmacol. 2012 May;166(2):447-56. doi: 10.1111/j.1476-5381.2012.01847.x. Br J Pharmacol. 2012. PMID: 22233238 Free PMC article. Review.
T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation.
Akaike T, Jin MH, Yokoyama U, Izumi-Nakaseko H, Jiao Q, Iwasaki S, Iwamoto M, Nishimaki S, Sato M, Yokota S, Kamiya Y, Adachi-Akahane S, Ishikawa Y, Minamisawa S. Akaike T, et al. Among authors: yokoyama u. J Biol Chem. 2009 Sep 4;284(36):24025-34. doi: 10.1074/jbc.M109.017061. Epub 2009 Jun 30. J Biol Chem. 2009. PMID: 19567868 Free PMC article.
116 results