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Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90.
Ryningen A, Ersvaer E, Øyan AM, Kalland KH, Vintermyr OK, Gjertsen BT, Bruserud Ø. Ryningen A, et al. Among authors: ersvaer e. Leuk Res. 2006 Dec;30(12):1531-40. doi: 10.1016/j.leukres.2006.02.014. Epub 2006 Apr 5. Leuk Res. 2006. PMID: 16600371
T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005.
Ersvaer E, Hampson P, Hatfield K, Ulvestad E, Wendelbo Ø, Lord JM, Gjertsen BT, Bruserud Ø. Ersvaer E, et al. Cancer Immunol Immunother. 2007 Jun;56(6):913-25. doi: 10.1007/s00262-006-0236-5. Epub 2006 Nov 8. Cancer Immunol Immunother. 2007. PMID: 17115221 Free PMC article.
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
Reikvam H, Hatfield KJ, Ersvaer E, Hovland R, Skavland J, Gjertsen BT, Petersen K, Bruserud O. Reikvam H, et al. Among authors: ersvaer e. Br J Haematol. 2012 Feb;156(4):468-80. doi: 10.1111/j.1365-2141.2011.08960.x. Epub 2011 Dec 13. Br J Haematol. 2012. PMID: 22150087 Free article.
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