Kim KW - Search Results

1

The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate.

Kim KW, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, Castro VM, Svensson S, Nybo R, Xiong F, Wang M. Kim KW, et al. Biochim Biophys Acta. 2006 Apr;1764(4):824-30. doi: 10.1016/j.bbapap.2006.02.008. Epub 2006 Mar 20. Biochim Biophys Acta. 2006. PMID: 16580270

2

The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding.

Kim KW, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, Castro VM, Svensson S, Nybo R, Xiong F, Wang M. Kim KW, et al. FEBS Lett. 2007 Mar 6;581(5):995-9. doi: 10.1016/j.febslet.2007.01.075. Epub 2007 Feb 8. FEBS Lett. 2007. PMID: 17306259 Free article.

3

High capacity homogeneous non-radioactive cortisol detection assays for human 11beta-hydroxysteroid dehydrogenase type 1.

Yu V, Tudor Y, Hale C, Plant M, Kim KW, Wang M, Nguyen Y, Miguel TS, Chen M, Nybo R, Baumgartner J, Kurzeja RJ, Powers D. Yu V, et al. Among authors: kim kw. Assay Drug Dev Technol. 2007 Feb;5(1):105-15. doi: 10.1089/adt.2006.047. Assay Drug Dev Technol. 2007. PMID: 17355203

4

Expression, purification, and characterization of human acetyl-CoA carboxylase 2.

Kim KW, Yamane H, Zondlo J, Busby J, Wang M. Kim KW, et al. Protein Expr Purif. 2007 May;53(1):16-23. doi: 10.1016/j.pep.2006.11.021. Epub 2006 Dec 9. Protein Expr Purif. 2007. PMID: 17223360

5

Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).

Véniant MM, Hale C, Hungate RW, Gahm K, Emery MG, Jona J, Joseph S, Adams J, Hague A, Moniz G, Zhang J, Bartberger MD, Li V, Syed R, Jordan S, Komorowski R, Chen MM, Cupples R, Kim KW, St Jean DJ Jr, Johansson L, Henriksson MA, Williams M, Vallgårda J, Fotsch C, Wang M. Véniant MM, et al. Among authors: kim kw. J Med Chem. 2010 Jun 10;53(11):4481-7. doi: 10.1021/jm100242d. J Med Chem. 2010. PMID: 20465278

6

A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase.

Lo MC, Wang M, Kim KW, Busby J, Yamane H, Zondlo J, Yuan C, Young SW, Xiao SH. Lo MC, et al. Among authors: kim kw. Anal Biochem. 2008 May 1;376(1):122-30. doi: 10.1016/j.ab.2008.01.033. Epub 2008 Feb 2. Anal Biochem. 2008. PMID: 18294446

7

Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.

Bourbeau MP, Siegmund A, Allen JG, Shu H, Fotsch C, Bartberger MD, Kim KW, Komorowski R, Graham M, Busby J, Wang M, Meyer J, Xu Y, Salyers K, Fielden M, Véniant MM, Gu W. Bourbeau MP, et al. Among authors: kim kw. J Med Chem. 2013 Dec 27;56(24):10132-41. doi: 10.1021/jm401601s. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24294923

8

Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening.

Liu Y, Zalameda L, Kim KW, Wang M, McCarter JD. Liu Y, et al. Among authors: kim kw. Assay Drug Dev Technol. 2007 Apr;5(2):225-35. doi: 10.1089/adt.2006.045. Assay Drug Dev Technol. 2007. PMID: 17477831

9

An optimized fast-performance liquid chromatography method for analyzing lipoprotein profiles using microliter volumes of serum.

Kim KW, McCormick J, Helmering J, Véniant MM, Wang M. Kim KW, et al. Anal Biochem. 2008 May 15;376(2):268-74. doi: 10.1016/j.ab.2008.02.028. Epub 2008 Mar 4. Anal Biochem. 2008. PMID: 18358227

10

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M. Beher D, et al. Among authors: kim kw. Chem Biol Drug Des. 2009 Dec;74(6):619-24. doi: 10.1111/j.1747-0285.2009.00901.x. Epub 2009 Oct 20. Chem Biol Drug Des. 2009. PMID: 19843076

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