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2D7 diabody bound to the alpha2 domain of HLA class I efficiently induces caspase-independent cell death against malignant and activated lymphoid cells.
Kimura N, Kawai S, Kinoshita Y, Ishiguro T, Azuma Y, Ozaki S, Abe M, Sugimoto M, Hirata Y, Orita T, Okabe H, Matsumoto T, Tsuchiya M. Kimura N, et al. Among authors: okabe h. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1201-9. doi: 10.1016/j.bbrc.2004.10.163. Biochem Biophys Res Commun. 2004. PMID: 15555554
Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
Kohchi Y, Hattori K, Oikawa N, Mizuguchi E, Isshiki Y, Aso K, Yoshinari K, Shirai H, Miwa M, Inagaki Y, Ura M, Ogawa K, Okabe H, Ishitsuka H, Shimma N. Kohchi Y, et al. Among authors: okabe h. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2241-5. doi: 10.1016/j.bmcl.2007.01.066. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17306533
[PTHrP and cancer cachexia].
Onuma E, Okabe H. Onuma E, et al. Among authors: okabe h. Clin Calcium. 2008 Apr;18(4):489-98. Clin Calcium. 2008. PMID: 18379031 Review. Japanese.
Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog.
Ohwada J, Ozawa S, Kohchi M, Fukuda H, Murasaki C, Suda H, Murata T, Niizuma S, Tsukazaki M, Ori K, Yoshinari K, Itezono Y, Endo M, Ura M, Tanimura H, Miyazaki Y, Kawashima A, Nagao S, Namba E, Ogawa K, Kobayashi K, Okabe H, Umeda I, Shimma N. Ohwada J, et al. Among authors: okabe h. Bioorg Med Chem Lett. 2009 May 15;19(10):2772-6. doi: 10.1016/j.bmcl.2009.03.123. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19362835
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.
Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schück V, Shimma N. Isshiki Y, et al. Among authors: okabe h. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801. doi: 10.1016/j.bmcl.2011.01.062. Epub 2011 Jan 21. Bioorg Med Chem Lett. 2011. PMID: 21316218
Synthesis of new camptothecin analogs with improved antitumor activities.
Niizuma S, Tsukazaki M, Suda H, Murata T, Ohwada J, Ozawa S, Fukuda H, Murasaki C, Kohchi M, Morikami K, Yoshinari K, Endo M, Ura M, Tanimura H, Miyazaki Y, Takasuka T, Kawashima A, Nanba E, Nakano K, Ogawa K, Kobayashi K, Okabe H, Umeda I, Shimma N. Niizuma S, et al. Among authors: okabe h. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. doi: 10.1016/j.bmcl.2009.02.031. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19254843
Asian Neonatal Network Collaboration (AsianNeo): a study protocol for international collaborative comparisons of health services and outcomes to improve quality of care for sick newborn infants in Asia - survey, cohort and quality improvement studies.
Isayama T, Miyake F, Rohsiswatmo R, Dewi R, Ozawa Y, Tomotaki S, Morisaki N, Chee SC, Neoh SH, Imperial MLS, Velasco BAE, Chang YS, Cho SJ, Youn Y, Quek BH, Poon WB, Amin Z, Jayaratne K, Kumara S, Lin YJ, Chang JH, Lin HY, Lin MC, Nuntnarumit P, Ngerncham S, Prempunpong C, Prempraphan P, Supapannachart S, Kusuda S; Asian Neonatal Network Collaboration (AsianNeo). Isayama T, et al. BMJ Open. 2024 Jul 13;14(7):e082712. doi: 10.1136/bmjopen-2023-082712. BMJ Open. 2024. PMID: 39388526 Free PMC article.
1,389 results