Karlsson A - Search Results

1

The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.

Balzarini J, Celen S, Karlsson A, de Groot T, Verbruggen A, Bormans G. Balzarini J, et al. Among authors: karlsson a. Antivir Chem Chemother. 2006;17(1):17-23. doi: 10.1177/095632020601700103. Antivir Chem Chemother. 2006. PMID: 16542002 Free article.

2

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.

Balzarini J, Hernández AI, Roche P, Esnouf R, Karlsson A, Camarasa MJ, Pérez-Pérez MJ. Balzarini J, et al. Among authors: karlsson a. Mol Pharmacol. 2003 Feb;63(2):263-70. doi: 10.1124/mol.63.2.263. Mol Pharmacol. 2003. PMID: 12527796

3

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.

Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A. Balzarini J, et al. Among authors: karlsson a. J Biol Chem. 2006 Jul 14;281(28):19273-9. doi: 10.1074/jbc.M600414200. Epub 2006 May 15. J Biol Chem. 2006. PMID: 16702226 Free article.

4

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.

Balzarini J, Van Daele I, Negri A, Solaroli N, Karlsson A, Liekens S, Gago F, Van Calenbergh S. Balzarini J, et al. Among authors: karlsson a. Mol Pharmacol. 2009 May;75(5):1127-36. doi: 10.1124/mol.108.053785. Epub 2009 Feb 20. Mol Pharmacol. 2009. PMID: 19233899

5

Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

Balzarini J, Gago F, Kulik W, van Kuilenburg AB, Karlsson A, Peterson MA, Robins MJ. Balzarini J, et al. Among authors: karlsson a. J Biol Chem. 2012 Aug 31;287(36):30444-54. doi: 10.1074/jbc.M112.378091. Epub 2012 Jun 24. J Biol Chem. 2012. PMID: 22730407 Free PMC article.

6

Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.

Balzarini J, Brouwer WG, Felauer EE, De Clercq E, Karlsson A. Balzarini J, et al. Among authors: karlsson a. Antiviral Res. 1995 Jun;27(3):219-36. doi: 10.1016/0166-3542(95)00006-8. Antiviral Res. 1995. PMID: 8540745

7

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

Van Poecke S, Negri A, Gago F, Van Daele I, Solaroli N, Karlsson A, Balzarini J, Van Calenbergh S. Van Poecke S, et al. Among authors: karlsson a. J Med Chem. 2010 Apr 8;53(7):2902-12. doi: 10.1021/jm901532h. J Med Chem. 2010. PMID: 20218622 Free article.

8

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.

Balzarini J, Karlsson A, Wang L, Bohman C, Horská K, Votruba I, Fridland A, Van Aerschot A, Herdewijn P, De Clercq E. Balzarini J, et al. Among authors: karlsson a. J Biol Chem. 1993 Nov 25;268(33):24591-8. J Biol Chem. 1993. PMID: 7901217 Free article.

9

Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2.

Balzarini J, Zhu C, De Clercq E, Pérez-Pérez MJ, Chamorro C, Camarasa MJ, Karlsson A. Balzarini J, et al. Among authors: karlsson a. Biochem J. 2000 Oct 1;351(Pt 1):167-71. doi: 10.1042/0264-6021:3510167. Biochem J. 2000. PMID: 10998359 Free PMC article.

10

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Hernandez AI, Familiar O, Negri A, Rodríguez-Barrios F, Gago F, Karlsson A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ. Hernandez AI, et al. Among authors: karlsson a. J Med Chem. 2006 Dec 28;49(26):7766-73. doi: 10.1021/jm0610550. J Med Chem. 2006. PMID: 17181158

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