Iizawa Y - Search Results

1

Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.

Seto M, Aikawa K, Miyamoto N, Aramaki Y, Kanzaki N, Takashima K, Kuze Y, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: iizawa y. J Med Chem. 2006 Mar 23;49(6):2037-48. doi: 10.1021/jm0509703. J Med Chem. 2006. PMID: 16539392

2

CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives.

Imamura S, Ishihara Y, Hattori T, Kurasawa O, Matsushita Y, Sugihara Y, Kanzaki N, Iizawa Y, Baba M, Hashiguchi S. Imamura S, et al. Among authors: iizawa y. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):63-73. doi: 10.1248/cpb.52.63. Chem Pharm Bull (Tokyo). 2004. PMID: 14709870 Free article.

3

CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas.

Imamura S, Kurasawa O, Nara Y, Ichikawa T, Nishikawa Y, Iida T, Hashiguchi S, Kanzaki N, Iizawa Y, Baba M, Sugihara Y. Imamura S, et al. Among authors: iizawa y. Bioorg Med Chem. 2004 May 1;12(9):2295-306. doi: 10.1016/j.bmc.2004.02.004. Bioorg Med Chem. 2004. PMID: 15080927

4

Orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety.

Seto M, Aramaki Y, Okawa T, Miyamoto N, Aikawa K, Kanzaki N, Niwa S, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: iizawa y. Chem Pharm Bull (Tokyo). 2004 May;52(5):577-90. doi: 10.1248/cpb.52.577. Chem Pharm Bull (Tokyo). 2004. PMID: 15133211 Free article.

5

Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety.

Seto M, Aramaki Y, Imoto H, Aikawa K, Oda T, Kanzaki N, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: iizawa y. Chem Pharm Bull (Tokyo). 2004 Jul;52(7):818-29. doi: 10.1248/cpb.52.818. Chem Pharm Bull (Tokyo). 2004. PMID: 15256702 Free article.

6

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety.

Seto M, Miyamoto N, Aikawa K, Aramaki Y, Kanzaki N, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: iizawa y. Bioorg Med Chem. 2005 Jan 17;13(2):363-86. doi: 10.1016/j.bmc.2004.10.021. Bioorg Med Chem. 2005. PMID: 15598559

7

CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives.

Imamura S, Nishikawa Y, Ichikawa T, Hattori T, Matsushita Y, Hashiguchi S, Kanzaki N, Iizawa Y, Baba M, Sugihara Y. Imamura S, et al. Among authors: iizawa y. Bioorg Med Chem. 2005 Jan 17;13(2):397-416. doi: 10.1016/j.bmc.2004.10.013. Bioorg Med Chem. 2005. PMID: 15598561

8

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.

Imamura S, Ichikawa T, Nishikawa Y, Kanzaki N, Takashima K, Niwa S, Iizawa Y, Baba M, Sugihara Y. Imamura S, et al. Among authors: iizawa y. J Med Chem. 2006 May 4;49(9):2784-93. doi: 10.1021/jm051034q. J Med Chem. 2006. PMID: 16640339

9

Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist.

Takashima K, Miyake H, Kanzaki N, Tagawa Y, Wang X, Sugihara Y, Iizawa Y, Baba M. Takashima K, et al. Among authors: iizawa y. Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82. doi: 10.1128/AAC.49.8.3474-3482.2005. Antimicrob Agents Chemother. 2005. PMID: 16048963 Free PMC article.

10

TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans.

Baba M, Takashima K, Miyake H, Kanzaki N, Teshima K, Wang X, Shiraishi M, Iizawa Y. Baba M, et al. Among authors: iizawa y. Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91. doi: 10.1128/AAC.49.11.4584-4591.2005. Antimicrob Agents Chemother. 2005. PMID: 16251299 Free PMC article. Clinical Trial.

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