Aikawa K - Search Results

1

Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.

Seto M, Aikawa K, Miyamoto N, Aramaki Y, Kanzaki N, Takashima K, Kuze Y, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: aikawa k. J Med Chem. 2006 Mar 23;49(6):2037-48. doi: 10.1021/jm0509703. J Med Chem. 2006. PMID: 16539392

2

Orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activity of 1-benzothiepine 1,1-dioxide and 1-benzazepine derivatives containing a tertiary amine moiety.

Seto M, Aramaki Y, Okawa T, Miyamoto N, Aikawa K, Kanzaki N, Niwa S, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: aikawa k. Chem Pharm Bull (Tokyo). 2004 May;52(5):577-90. doi: 10.1248/cpb.52.577. Chem Pharm Bull (Tokyo). 2004. PMID: 15133211 Free article.

3

Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety.

Seto M, Aramaki Y, Imoto H, Aikawa K, Oda T, Kanzaki N, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: aikawa k. Chem Pharm Bull (Tokyo). 2004 Jul;52(7):818-29. doi: 10.1248/cpb.52.818. Chem Pharm Bull (Tokyo). 2004. PMID: 15256702 Free article.

4

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety.

Seto M, Miyamoto N, Aikawa K, Aramaki Y, Kanzaki N, Iizawa Y, Baba M, Shiraishi M. Seto M, et al. Among authors: aikawa k. Bioorg Med Chem. 2005 Jan 17;13(2):363-86. doi: 10.1016/j.bmc.2004.10.021. Bioorg Med Chem. 2005. PMID: 15598559

5

Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.

Yamamoto S, Kobayashi H, Kaku T, Aikawa K, Hara T, Yamaoka M, Kanzaki N, Hasuoka A, Baba A, Ito M. Yamamoto S, et al. Among authors: aikawa k. Bioorg Med Chem. 2013 Jan 1;21(1):70-83. doi: 10.1016/j.bmc.2012.11.001. Epub 2012 Nov 12. Bioorg Med Chem. 2013. PMID: 23199477

6

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.

Aikawa K, Miyawaki T, Hitaka T, Imai YN, Hara T, Miyazaki J, Yamaoka M, Kusaka M, Kanzaki N, Tasaka A, Shiraishi M, Yamamoto S. Aikawa K, et al. Bioorg Med Chem. 2015 May 15;23(10):2568-78. doi: 10.1016/j.bmc.2015.03.032. Epub 2015 Mar 19. Bioorg Med Chem. 2015. PMID: 25862209

7

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Tanaka Y, Aikawa K, Nishida G, Homma M, Sogabe S, Igaki S, Hayano Y, Sameshima T, Miyahisa I, Kawamoto T, Tawada M, Imai Y, Inazuka M, Cho N, Imaeda Y, Ishikawa T. Tanaka Y, et al. Among authors: aikawa k. J Med Chem. 2013 Dec 12;56(23):9635-45. doi: 10.1021/jm401170c. Epub 2013 Dec 2. J Med Chem. 2013. PMID: 24215352

8

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.

Aikawa K, Asano M, Ono K, Habuka N, Yano J, Wilson K, Fujita H, Kandori H, Hara T, Morimoto M, Santou T, Yamaoka M, Nakayama M, Hasuoka A. Aikawa K, et al. Bioorg Med Chem. 2017 Jul 1;25(13):3330-3349. doi: 10.1016/j.bmc.2017.04.018. Epub 2017 Apr 13. Bioorg Med Chem. 2017. PMID: 28454849

9

A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.

Sameshima T, Miyahisa I, Homma M, Aikawa K, Hixon MS, Matsui J. Sameshima T, et al. Among authors: aikawa k. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5836-5839. doi: 10.1016/j.bmcl.2014.09.073. Epub 2014 Oct 2. Bioorg Med Chem Lett. 2014. PMID: 25452002

10

Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models.

Morimoto M, Aikawa K, Hara T, Yamaoka M. Morimoto M, et al. Among authors: aikawa k. Oncol Lett. 2017 Dec;14(6):8066-8071. doi: 10.3892/ol.2017.7200. Epub 2017 Oct 17. Oncol Lett. 2017. PMID: 29344250 Free PMC article.

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