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The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.
Di Modugno F, Mottolese M, Di Benedetto A, Conidi A, Novelli F, Perracchio L, Venturo I, Botti C, Jager E, Santoni A, Natali PG, Nisticò P. Di Modugno F, et al. Among authors: santoni a. Clin Cancer Res. 2006 Mar 1;12(5):1470-8. doi: 10.1158/1078-0432.CCR-05-2027. Clin Cancer Res. 2006. PMID: 16533770 Free article.
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.
Di Modugno F, DeMonte L, Balsamo M, Bronzi G, Nicotra MR, Alessio M, Jager E, Condeelis JS, Santoni A, Natali PG, Nisticò P. Di Modugno F, et al. Among authors: santoni a. Cancer Res. 2007 Mar 15;67(6):2657-65. doi: 10.1158/0008-5472.CAN-06-1997. Cancer Res. 2007. PMID: 17363586 Free PMC article.
The cooperation between hMena overexpression and HER2 signalling in breast cancer.
Di Modugno F, Mottolese M, DeMonte L, Trono P, Balsamo M, Conidi A, Melucci E, Terrenato I, Belleudi F, Torrisi MR, Alessio M, Santoni A, Nisticò P. Di Modugno F, et al. Among authors: santoni a. PLoS One. 2010 Dec 30;5(12):e15852. doi: 10.1371/journal.pone.0015852. PLoS One. 2010. PMID: 21209853 Free PMC article.
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.
Di Modugno F, Iapicca P, Boudreau A, Mottolese M, Terrenato I, Perracchio L, Carstens RP, Santoni A, Bissell MJ, Nisticò P. Di Modugno F, et al. Among authors: santoni a. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19280-5. doi: 10.1073/pnas.1214394109. Epub 2012 Nov 5. Proc Natl Acad Sci U S A. 2012. PMID: 23129656 Free PMC article.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, Gismondi A, Santoni A, Nisticò P. Franzese O, et al. Among authors: santoni a. Oncoimmunology. 2016 Feb 1;5(5):e1114203. doi: 10.1080/2162402X.2015.1114203. eCollection 2016 May. Oncoimmunology. 2016. PMID: 27467927 Free PMC article.
hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.
Di Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P. Di Modugno F, et al. Among authors: santoni a. Oncogene. 2018 Oct;37(42):5605-5617. doi: 10.1038/s41388-018-0364-3. Epub 2018 Jun 15. Oncogene. 2018. PMID: 29907768 Free PMC article.
536 results