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Psychosis pathways converge via D2high dopamine receptors.
Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS, Roder JC, Quirion R, Boksa P, Srivastava LK, Yanai K, Weinshenker D, Sumiyoshi T. Seeman P, et al. Synapse. 2006 Sep 15;60(4):319-46. doi: 10.1002/syn.20303. Synapse. 2006. PMID: 16786561 Review.
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Seeman P, Weinshenker D, Quirion R, Srivastava LK, Bhardwaj SK, Grandy DK, Premont RT, Sotnikova TD, Boksa P, El-Ghundi M, O'dowd BF, George SR, Perreault ML, Männistö PT, Robinson S, Palmiter RD, Tallerico T. Seeman P, et al. Among authors: perreault ml. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3513-8. doi: 10.1073/pnas.0409766102. Epub 2005 Feb 16. Proc Natl Acad Sci U S A. 2005. PMID: 15716360 Free PMC article.
Disruption of a dopamine receptor complex amplifies the actions of cocaine.
Perreault ML, Hasbi A, Shen MYF, Fan T, Navarro G, Fletcher PJ, Franco R, Lanciego JL, George SR. Perreault ML, et al. Eur Neuropsychopharmacol. 2016 Sep;26(9):1366-1377. doi: 10.1016/j.euroneuro.2016.07.008. Epub 2016 Jul 30. Eur Neuropsychopharmacol. 2016. PMID: 27480020
52 results