Jhoti H - Search Results

1

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Howard N, et al. Among authors: jhoti h. J Med Chem. 2006 Feb 23;49(4):1346-55. doi: 10.1021/jm050850v. J Med Chem. 2006. PMID: 16480269

2

Fragment-based lead discovery using X-ray crystallography.

Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Hartshorn MJ, et al. Among authors: jhoti h. J Med Chem. 2005 Jan 27;48(2):403-13. doi: 10.1021/jm0495778. J Med Chem. 2005. PMID: 15658854

3

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H. Gill AL, et al. Among authors: jhoti h. J Med Chem. 2005 Jan 27;48(2):414-26. doi: 10.1021/jm049575n. J Med Chem. 2005. PMID: 15658855

4

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B.

van Montfort RL, Congreve M, Tisi D, Carr R, Jhoti H. van Montfort RL, et al. Among authors: jhoti h. Nature. 2003 Jun 12;423(6941):773-7. doi: 10.1038/nature01681. Nature. 2003. PMID: 12802339

5

A 'rule of three' for fragment-based lead discovery?

Congreve M, Carr R, Murray C, Jhoti H. Congreve M, et al. Among authors: jhoti h. Drug Discov Today. 2003 Oct 1;8(19):876-7. doi: 10.1016/s1359-6446(03)02831-9. Drug Discov Today. 2003. PMID: 14554012 No abstract available.

6

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.

Saalau-Bethell SM, Woodhead AJ, Chessari G, Carr MG, Coyle J, Graham B, Hiscock SD, Murray CW, Pathuri P, Rich SJ, Richardson CJ, Williams PA, Jhoti H. Saalau-Bethell SM, et al. Among authors: jhoti h. Nat Chem Biol. 2012 Nov;8(11):920-5. doi: 10.1038/nchembio.1081. Epub 2012 Sep 30. Nat Chem Biol. 2012. PMID: 23023261 Free PMC article.

7

Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.

Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H. Saalau-Bethell SM, et al. Among authors: jhoti h. ChemMedChem. 2014 Apr;9(4):823-32. doi: 10.1002/cmdc.201300480. Epub 2014 Feb 24. ChemMedChem. 2014. PMID: 24616449 Free PMC article.

8

Detection of ligands from a dynamic combinatorial library by X-ray crystallography.

Congreve MS, Davis DJ, Devine L, Granata C, O'Reilly M, Wyatt PG, Jhoti H. Congreve MS, et al. Among authors: jhoti h. Angew Chem Int Ed Engl. 2003 Sep 29;42(37):4479-82. doi: 10.1002/anie.200351951. Angew Chem Int Ed Engl. 2003. PMID: 14520743 No abstract available.

9

High-throughput crystallography for lead discovery in drug design.

Blundell TL, Jhoti H, Abell C. Blundell TL, et al. Among authors: jhoti h. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. doi: 10.1038/nrd706. Nat Rev Drug Discov. 2002. PMID: 12119609 Review.

10

Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design.

O'Reilly M, Cleasby A, Davies TG, Hall RJ, Ludlow RF, Murray CW, Tisi D, Jhoti H. O'Reilly M, et al. Among authors: jhoti h. Drug Discov Today. 2019 May;24(5):1081-1086. doi: 10.1016/j.drudis.2019.03.009. Epub 2019 Mar 14. Drug Discov Today. 2019. PMID: 30878562 Free article. Review.

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