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Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages.
Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I. Yang SR, et al. Among authors: kilty i. Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L46-57. doi: 10.1152/ajplung.00241.2005. Epub 2006 Feb 10. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16473865 Free article.
Antioxidant therapeutic targets in COPD.
Rahman I, Kilty I. Rahman I, et al. Among authors: kilty i. Curr Drug Targets. 2006 Jun;7(6):707-20. doi: 10.2174/138945006777435254. Curr Drug Targets. 2006. PMID: 16787173 Review.
Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD.
Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Andò F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH. Ngkelo A, et al. Among authors: kilty i. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 26320152 Free PMC article.
Cigarette smoke induced airway inflammation is independent of NF-κB signalling.
Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA. Rastrick JM, et al. Among authors: kilty i. PLoS One. 2013;8(1):e54128. doi: 10.1371/journal.pone.0054128. Epub 2013 Jan 22. PLoS One. 2013. PMID: 23349803 Free PMC article.
Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.
Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP. Bewley MA, et al. Among authors: kilty i. PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016. PLoS One. 2016. PMID: 27680884 Free PMC article.
Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.
Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP. Bewley MA, et al. Among authors: kilty i. Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC. Am J Respir Crit Care Med. 2018. PMID: 29547002 Free PMC article.
44 results