Cordell B - Search Results

1

Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.

Thompson LA, Liauw AY, Ramanjulu MM, Kasireddy-Polam P, Mercer SE, Maduskuie TP, Glicksman M, Roach AH, Meredith JE, Liu RQ, Combs AP, Higaki JN, Cordell B, Seiffert D, Zaczek RC, Robertson DW, Olson RE. Thompson LA, et al. Among authors: cordell b. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. doi: 10.1016/j.bmcl.2006.01.055. Epub 2006 Feb 10. Bioorg Med Chem Lett. 2006. PMID: 16473009

2

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.

Seiffert D, Bradley JD, Rominger CM, Rominger DH, Yang F, Meredith JE Jr, Wang Q, Roach AH, Thompson LA, Spitz SM, Higaki JN, Prakash SR, Combs AP, Copeland RA, Arneric SP, Hartig PR, Robertson DW, Cordell B, Stern AM, Olson RE, Zaczek R. Seiffert D, et al. Among authors: cordell b. J Biol Chem. 2000 Nov 3;275(44):34086-91. doi: 10.1074/jbc.M005430200. J Biol Chem. 2000. PMID: 10915801 Free article.

3

Amyloid forming proteases: therapeutic targets for Alzheimer's disease.

Schimmöller F, Higaki JN, Cordell B. Schimmöller F, et al. Among authors: cordell b. Curr Pharm Des. 2002;8(28):2521-31. doi: 10.2174/1381612023392658. Curr Pharm Des. 2002. PMID: 12369937 Review.

4

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production.

Higaki JN, Chakravarty S, Bryant CM, Cowart LR, Harden P, Scardina JM, Mavunkel B, Luedtke GR, Cordell B. Higaki JN, et al. Among authors: cordell b. J Med Chem. 1999 Sep 23;42(19):3889-98. doi: 10.1021/jm990009f. J Med Chem. 1999. PMID: 10508437

5

Inhibition of beta-amyloid formation by haloperidol: a possible mechanism for reduced frequency of Alzheimer's disease pathology in schizophrenia.

Higaki J, Murphy GM Jr, Cordell B. Higaki J, et al. Among authors: cordell b. J Neurochem. 1997 Jan;68(1):333-6. doi: 10.1046/j.1471-4159.1997.68010333.x. J Neurochem. 1997. PMID: 8978743 Free article.

6

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism.

Higaki J, Quon D, Zhong Z, Cordell B. Higaki J, et al. Among authors: cordell b. Neuron. 1995 Mar;14(3):651-9. doi: 10.1016/0896-6273(95)90322-4. Neuron. 1995. PMID: 7695912 Free article.

7

Increased amyloid production from aberrant beta-amyloid precursor proteins.

Zhong Z, Quon D, Higgins LS, Higaki J, Cordell B. Zhong Z, et al. Among authors: cordell b. J Biol Chem. 1994 Apr 22;269(16):12179-84. J Biol Chem. 1994. PMID: 8163522 Free article.

8

Processing of beta-amyloid precursor protein by cathepsin D.

Higaki J, Catalano R, Guzzetta AW, Quon D, Navé JF, Tarnus C, D'Orchymont H, Cordell B. Higaki J, et al. Among authors: cordell b. J Biol Chem. 1996 Dec 13;271(50):31885-93. doi: 10.1074/jbc.271.50.31885. J Biol Chem. 1996. PMID: 8943232 Free article.

9

Secretion of beta-amyloid precursor protein involves multiple cleavage sites.

Zhong Z, Higaki J, Murakami K, Wang Y, Catalano R, Quon D, Cordell B. Zhong Z, et al. Among authors: cordell b. J Biol Chem. 1994 Jan 7;269(1):627-32. J Biol Chem. 1994. PMID: 8276862 Free article.

10

Novel functional assay for proteases and modulators. Application in beta-secretase studies.

Li Y, Liu YW, Cordell B. Li Y, et al. Among authors: cordell b. Mol Biotechnol. 2001 May;18(1):1-10. doi: 10.1385/MB:18:1:01. Mol Biotechnol. 2001. PMID: 11439695

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