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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.
Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, Chien S, Chiu JJ. Tsai MC, et al. Among authors: wang y, wang n. Circ Res. 2009 Aug 28;105(5):471-80. doi: 10.1161/CIRCRESAHA.109.193656. Epub 2009 Jul 23. Circ Res. 2009. PMID: 19628794 Free PMC article.
LDL-activated p38 in endothelial cells is mediated by Ras.
Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy JY, Chien S, Stemerman MB. Zhu Y, et al. Among authors: wang n. Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1159-64. doi: 10.1161/hq0701.092473. Arterioscler Thromb Vasc Biol. 2001. PMID: 11451745
Shear stress activation of nuclear receptor PXR in endothelial detoxification.
Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li YS, Shyy JY, Guan Y, Chien S, Wang N. Wang X, et al. Among authors: wang n. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13174-9. doi: 10.1073/pnas.1312065110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878263 Free PMC article.
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